Study of Sh2d1a Gene Mutation in Paediatric Patients With B-Cell Lymphoma

Study of Sh2d1a Gene Mutation in Paediatric Patients With B-Cell Lymphoma Publisher Pubmed

Koochakzadeh L¹ ; Hosseinverdi S^{1, 2} ; Hedayat M³ ; Farahani F¹ ; Tofighi A¹ ; Eghbali M¹ ; Bidoki AZ⁴ ; Izadyar M¹ ; Rahiminejad MS¹ ; Ramyar A¹ ; Aghamohammadi A^{1, 2} ; Rezaei N^{1, 2, 4, 5}

Show Affiliations

1. Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
2. Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
3. Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States
4. Molecular Immunology Research Center, Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
5. Universal Scientific Education and Research Network (USERN), Tehran, Iran

Source: Allergologia et Immunopathologia Published:2015

Abstract

Background: X-linked lymphoproliferative disease (XLP) is an often fatal inherited immunodeficiency disorder characterised by fulminant infectious mononucleosis, acquired haemophagocytic lymphohistiocytosis, dysgammaglobulinaemia and malignant lymphoma. Given the paucity of data on the genetic stratification of XLP gene mutations in paediatric patients diagnosed with B-cell lymphoma, we sought to determine the existence of such association in the present study. Methods: We studied 20 male subjects diagnosed with non-Hodgkin B-cell lymphoma. Results: Eleven patients had laboratory evidence of EBV infection by serology and quantitative PCR. The SH2D1A gene analysis was negative in all patients. Conclusions: This is the first study to analyse the SH2D1A gene mutations in Iranian paediatric patients diagnosed with lymphoma. Although we could not demonstrate such an association in our cohort of patients, larger, multi-centre studies are required to extend and confirm our early findings. © 2014 SEICAP.

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Style	Citing Format
MLA	Koochakzadeh L, et al.. "Study of Sh2d1a Gene Mutation in Paediatric Patients With B-Cell Lymphoma." Allergologia et Immunopathologia, vol. 43, no. 6, 2015, pp. 568-570.
APA	Koochakzadeh L, Hosseinverdi S, Hedayat M, Farahani F, Tofighi A, Eghbali M, Bidoki AZ, Izadyar M, Rahiminejad MS, Ramyar A, Aghamohammadi A, Rezaei N (2015). Study of Sh2d1a Gene Mutation in Paediatric Patients With B-Cell Lymphoma. Allergologia et Immunopathologia, 43(6), 568-570.
Chicago	Koochakzadeh L, Hosseinverdi S, Hedayat M, Farahani F, Tofighi A, Eghbali M, Bidoki AZ, et al.. "Study of Sh2d1a Gene Mutation in Paediatric Patients With B-Cell Lymphoma." Allergologia et Immunopathologia 43, no. 6 (2015): 568-570.
Harvard	Koochakzadeh L et al. (2015) 'Study of Sh2d1a Gene Mutation in Paediatric Patients With B-Cell Lymphoma', Allergologia et Immunopathologia, 43(6), pp. 568-570.
Vancouver	Koochakzadeh L, Hosseinverdi S, Hedayat M, Farahani F, Tofighi A, Eghbali M, et al.. Study of Sh2d1a Gene Mutation in Paediatric Patients With B-Cell Lymphoma. Allergologia et Immunopathologia. 2015;43(6):568-570.
BibTex	@article{ author = {Koochakzadeh L and Hosseinverdi S and Hedayat M and Farahani F and Tofighi A and Eghbali M and Bidoki AZ and Izadyar M and Rahiminejad MS and Ramyar A and Aghamohammadi A and Rezaei N}, title = {Study of Sh2d1a Gene Mutation in Paediatric Patients With B-Cell Lymphoma}, journal = {Allergologia et Immunopathologia}, volume = {43}, number = {6}, pages = {568-570}, year = {2015} }
RIS	TY - JOUR AU - Koochakzadeh L AU - Hosseinverdi S AU - Hedayat M AU - Farahani F AU - Tofighi A AU - Eghbali M AU - Bidoki AZ AU - Izadyar M AU - Rahiminejad MS AU - Ramyar A AU - Aghamohammadi A AU - Rezaei N TI - Study of Sh2d1a Gene Mutation in Paediatric Patients With B-Cell Lymphoma JO - Allergologia et Immunopathologia VL - 43 IS - 6 SP - 568 EP - 570 PY - 2015 ER -

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