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Common Presentations and Diagnostic Approaches Publisher



Rezaei N1, 2 ; De Vries E3, 4 ; Gambineri E5, 6 ; Meyts I7 ; Haddad E8
Authors
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Authors Affiliations
  1. 1. Research Center for Immunodeficiencies, Children's Medical Center and Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  3. 3. Department Tranzo, The Scientific Center for Care and Wellbeing, Tilburg University, Tilburg, Netherlands
  4. 4. Laboratory for Medical Microbiology and Immunology, Elisabeth Tweesteden Hospital, Tilburg, Netherlands
  5. 5. Department of “NEUROFARBA�, Section of Child’s Health, University of Florence, Florence, Italy
  6. 6. Department of Haematology-Oncology, BMT Unit “Anna Meyer� Children’s Hospital, Florence, Italy
  7. 7. Department of Pediatrics, University Hospitals Leuven, Laboratory for Inborn Errors of Immunity, Department of Immunology, Microbiology and Transplantation, KU Leuven, Leuven, Belgium
  8. 8. Pediatric Immunology and Rheumatology Division, CHU Sainte-Justine, Department of Pediatrics, University of Montreal, Montreal, QC, Canada

Source: Stiehm's Immune Deficiencies: Inborn Errors of Immunity Published:2020


Abstract

Primary immune deficiencies are a heterogeneous group of inherited disorders generally caused by specific gene mutations affecting the immune system and leading to various clinical manifestations, including severe infections, autoimmunity, and malignancies. In this chapter, general considerations on primary immune deficiency as well as the various circumstances in which a primary immune deficiency is evoked are described. This chapter serves as a roadmap to understand the layout of this book and it mirrors the clinical approach taken by immunologists. © 2020 Elsevier Inc. All rights reserved.
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