Epigenetic Modifications in Gastric Cancer: Focus on Dna Methylation

Epigenetic Modifications in Gastric Cancer: Focus on Dna Methylation Publisher Pubmed

Ebrahimi V^{1, 2} ; Soleimanian A^{1, 3} ; Ebrahimi T⁴ ; Azargun R⁵ ; Yazdani P¹ ; Eyvazi S⁶ ; Tarhriz V¹

Show Affiliations

1. Molecular Medicine Research Center, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran
2. Department of Pharmaceutical Biotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3. Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran
4. Department of NanoBiotechnology Reseaech Center, Pasteur Institute of Iran, Tehran, Iran
5. Department of Microbiology, Faculty of Medicine, Maragheh University of Medical Sciences, Maragheh, Iran
6. Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Gene Published:2020

Abstract

Gastric cancer is a complex heterogeneous disease which is the fourth prevalent malignancy worldwide. Although, several diagnosis and treatment are available for the gastric cancer patients, however the malignancy is still the third leading cause of cancer-related death in the world. Beside the genetic and environmental factors, epigenetic alterations are also involved in the emergence of gastric cancer. Epigenetics alterations are heritable changes which regulate gene expression without occurring changes in DNA sequence. Epigenetic changes mostly include DNA methylation, histon post-translational modifications, chromatin remodeling and non-coding RNAs. Among the mentioned epigenetic modifications, DNA methylation is a major epigenetic process that plays a key role in different stages of evolution and cancer development. In this review, we address all types of related epigenetic modifications in gastric cancer by focus on DNA methylation by reviewing the recent literatures. Understanding of molecular mechanisms of epigenetics alterations in gastric cancer development helps researchers to identify new epigenetic drugs against the malignancy. © 2020

Related Docs

View other Related Docs

1. The Role of Dna Methylation in Cancer, Cancer Immunology: A Translational Medicine Context# Second Edition (2020)

2. Epigenetic Changes Underlie the Association Between Diabetes Mellitus and Oral Diseases, Molecular Biology Reports (2023)

3. Epigenetic Regulation in Oral Squamous Cell Carcinoma Microenvironment: A Comprehensive Review, Cancers (2023)

4. Dna Methylation in Human Diseases, Heliyon (2024)

5. The Role of Dna Methylation in Progression of Neurological Disorders and Neurodegenerative Diseases As Well As the Prospect of Using Dna Methylation Inhibitors As Therapeutic Agents for Such Disorders, IBRO Neuroscience Reports (2023)

6. Dysregulated Expression of Mir-146A and Its Associated Immune Effectors in Peripheral Blood Mononuclear Cells of Esophageal Carcinoma Patients, Immunological Investigations (2022)

7. An Insight Into the Roles of Pirnas and Piwi Proteins in the Diagnosis and Pathogenesis of Oral, Esophageal, and Gastric Cancer, Pathology Research and Practice (2020)

8. Epigenetic Drugs As New Emerging Therapeutics: What Is the Scale's Orientation of Application and Challenges?, Pathology Research and Practice (2023)

Experts (# of related papers)

View all Related Experts

Nima Rezaei (1)

Mohammad Ali Mansournia (1)

Style	Citing Format
MLA	Ebrahimi V, et al.. "Epigenetic Modifications in Gastric Cancer: Focus on Dna Methylation." Gene, vol. 742, no. , 2020, pp. -.
APA	Ebrahimi V, Soleimanian A, Ebrahimi T, Azargun R, Yazdani P, Eyvazi S, Tarhriz V (2020). Epigenetic Modifications in Gastric Cancer: Focus on Dna Methylation. Gene, 742(), -.
Chicago	Ebrahimi V, Soleimanian A, Ebrahimi T, Azargun R, Yazdani P, Eyvazi S, Tarhriz V. "Epigenetic Modifications in Gastric Cancer: Focus on Dna Methylation." Gene 742, no. (2020): -.
Harvard	Ebrahimi V et al. (2020) 'Epigenetic Modifications in Gastric Cancer: Focus on Dna Methylation', Gene, 742(), pp. -.
Vancouver	Ebrahimi V, Soleimanian A, Ebrahimi T, Azargun R, Yazdani P, Eyvazi S, et al.. Epigenetic Modifications in Gastric Cancer: Focus on Dna Methylation. Gene. 2020;742():-.
BibTex	@article{ author = {Ebrahimi V and Soleimanian A and Ebrahimi T and Azargun R and Yazdani P and Eyvazi S and Tarhriz V}, title = {Epigenetic Modifications in Gastric Cancer: Focus on Dna Methylation}, journal = {Gene}, volume = {742}, number = {}, pages = {-}, year = {2020} }
RIS	TY - JOUR AU - Ebrahimi V AU - Soleimanian A AU - Ebrahimi T AU - Azargun R AU - Yazdani P AU - Eyvazi S AU - Tarhriz V TI - Epigenetic Modifications in Gastric Cancer: Focus on Dna Methylation JO - Gene VL - 742 IS - SP - EP - PY - 2020 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract