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Complementary Role of Ultrasound in Management of Gestational Trophoblastic Disease Publisher



Malek M1 ; Moradi B1 ; Mousavi AS2 ; Ahmadinejad N1 ; Kazemi MA1 ; Gity M1
Authors
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Authors Affiliations
  1. 1. Department of Radiology, Advanced Diagnostic and Interventional Radiology Research Center (ADIR), Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Gynecology Oncology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran

Source: Iranian Journal of Radiology Published:2015


Abstract

Background: Transvaginal Ultrasonography is a noninvasive and inexpensive medical imaging tool used for the diagnosis of various diseases. Objectives: To identify an effective method to identify high-risk patients for developing malignancy after molar evacuation. Patients and Methods: A prospective serial assessment of 19 patients with gestational trophoblastic disease was performed. Clinical and laboratory data, transvaginal ultrasound and Doppler findings were evaluated the day before evacuation. They were followed-up in the first week after evacuation and every two weeks during the next two months, then every month until the sixth month. Results: Ovarian theca lutein cysts (P = 0.018) (among pre-evacuation factors) and first week ultrasound (P = 0.02) can help in detecting high-risk patients. Even though, when β-hCG titer is not available in a high-risk patient, post evacuation myometrial involvement (P = 0.005) is a useful sign for detecting persistency. Conclusions: Some ultrasonographic features of molar pregnancy have capability to predict malignancy in the course of disease. © 2015, Tehran University of Medical Sciences and Iranian Society of Radiology.