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The Role of Micrornas in Respiratory Viral Infection: Friend or Foe? Publisher Pubmed



Tahamtan A1 ; Inchley CS2 ; Marzban M1 ; Tavakoliyaraki M4 ; Teymoorirad M1 ; Nakstad B2, 3 ; Salimi V1
Authors
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Authors Affiliations
  1. 1. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Pediatric and Adolescent Medicine, Akershus University Hospital, Lorenskog, Norway
  3. 3. Institute of Clinical Medicine, University of Oslo, Oslo, Norway
  4. 4. Department of Biochemistry, school of Medicine, Iran University of Medical Sciences, Tehran, Iran

Source: Reviews in Medical Virology Published:2016


Abstract

MicroRNAs (miRNAs) have emerged as a class of regulatory RNAs in host–pathogen interactions. Aberrant miRNA expression seems to play a central role in the pathology of several respiratory viruses, promoting development and progression of infection. miRNAs may thus serve as therapeutic and prognostic factors for respiratory viral infectious disease caused by a variety of agents. We present a comprehensive review of recent findings related to the role of miRNAs in different respiratory viral infections and discuss possible therapeutic opportunities aiming to attenuate the burden of viral infections. Our review supports the emerging concept that cellular and viral-encoded miRNAs might be broadly implicated in human respiratory viral infections, with either positive or negative effects on virus life cycle. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.
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