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Exosomes As Cutting-Edge Therapeutics in Various Biomedical Applications: An Update on Engineering, Delivery, and Preclinical Studies Publisher Pubmed



Mehryab F1 ; Taghizadeh F1 ; Goshtasbi N1 ; Merati F1 ; Rabbani S2 ; Haeri A1, 3
Authors
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Authors Affiliations
  1. 1. Department of Pharmaceutics and Pharmaceutical Nanotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Research Center for Advanced Technologies in Cardiovascular Medicine, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Protein Technology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Biochimie Published:2023


Abstract

Exosomes are cell-derived nanovesicles, circulating in different body fluids, and acting as an intercellular mechanism. They can be purified from culture media of different cell types and carry an enriched content of various protein and nucleic acid molecules originating from their parental cells. It was indicated that the exosomal cargo can mediate immune responses via many signaling pathways. Over recent years, the therapeutic effects of various exosome types were broadly investigated in many preclinical studies. Herein, we present an update on recent preclinical studies on exosomes as therapeutic and/or delivery agents for various applications. The exosome origin, structural modifications, natural or loaded active ingredients, size, and research outcomes were summarized for various diseases. Overall, the present article provides an overview of the latest exosome research interests and developments to clear the way for the clinical study design and application. © 2023 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM)
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