Tehran University of Medical Sciences

Science Communicator Platform

Share By
Alternative Approaches to Combatting Klebsiella Pneumoniae Biofilms: A Comprehensive Review Publisher Pubmed



Roustaye Gourabi MJ ; Nikoo A ; Yarahmadi Saki Y ; Khanbabaei B ; Fayyazi A ; Mousavi SMJ ; Aghdaee A ; Kargar M ; Hashemi A ; Sharahi JY
Authors

Source: Microbial Pathogenesis Published:2026


Abstract

Biofilms are microbial communities encased in an extracellular matrix, forming highly resistant structures. Klebsiella pneumoniae, a major opportunistic pathogen, exhibits strong biofilm-forming ability, posing serious challenges in healthcare and industry. Key issues include extreme antimicrobial resistance, immune evasion, and complex organization. Currently, no approved treatments specifically target K. pneumoniae biofilms, necessitating alternative strategies. A combined approach is essential for effective control. This review explores potential alternative therapies to complement conventional treatments, enhancing antibiotic efficacy and mitigating the harmful effects of these resilient bacterial communities. © 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
Related Docs
View other Related Docs
1. Advanced Strategies for Combating Bacterial Biofilms, Journal of Cellular Physiology (2019)
2. Advancing Anti-Biofilm Strategies: Innovations to Combat Biofilm-Related Challenges and Enhance Efficacy, Journal of Basic Microbiology (2024)
3. The Inhibitory Effects of Lactobacillus Supernatants and Their Metabolites on the Growth and Biofilm Formation of Klebsiella Pneumoniae, Infectious Disorders - Drug Targets (2020)
Experts (# of related papers)
View all Related Experts
Mohammad Emaneini (3)
Fereshteh Jabalameli (3)
Other Related Docs
4. Breaking the Biofilm Barrier: Nano-Based Antibacterial Delivery, Medicine in Novel Technology and Devices (2026)
5. From Cure to Crisis: Understanding the Evolution of Antibiotic-Resistant Bacteria in Human Microbiota, Biomolecules (2025)
6. The Importance of Intracellular Bacterial Biofilm in Infectious Diseases, Microbial Pathogenesis (2020)
7. Staphylococcus Aureus: Biofilm Formation and Strategies Against It, Current Pharmaceutical Biotechnology (2022)
8. Evaluation of Biofilm Formation Among Klebsiella Pneumoniae Isolates and Molecular Characterization by Eric-Pcr, Jundishapur Journal of Microbiology (2016)
9. Probiotics, Prebiotics, Synbiotics, Postbiotics, and Bioactive Agents in Modulating Harmful Oral Biofilms, Probiotics and Antimicrobial Proteins (2025)
10. In Vitro Antibiotic Combinations of Colistin, Meropenem, Amikacin, and Amoxicillin/Clavulanate Against Multidrug-Resistant Klebsiella Pneumonia Isolated From Patients With Ventilator-Associated Pneumonia, BMC Microbiology (2023)
11. The in Vitro Evaluation of Synergistic Effects of Ciprofloxacin and Berberine Hydrochloride Against Pseudomonas Aeruginosa, BMC Microbiology (2025)
12. Association Between Presence of Rmpa, Mrka and Mrkd Genes and Antibiotic Resistance in Clinical Klebsiella Pneumoniae Isolates From Hospitals in Tehran, Iran, Iranian Journal of Public Health (2021)
13. Combinatorial Effects of Antibiotics and Enzymes Against Dual-Species Staphylococcus Aureus and Pseudomonas Aeruginosa Biofilms in the Wound-Like Medium, PLoS ONE (2020)
14. The Biofilm-Associated Bacterial Infections Unrelated to Indwelling Devices, IUBMB Life (2020)
15. Combined Forces Against Bacteria: Phages and Antibiotics, Health Science Reports (2025)
16. Characterization of Biofilm Formation Ability, Virulence Factors and Antibiotic Resistance Pattern of Staphylococcus Aureus Isolates From Subclinical Bovine Mastitis, Iranian Journal of Veterinary Medicine (2022)