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The Importance of Intracellular Bacterial Biofilm in Infectious Diseases Publisher Pubmed



Mirzaei R1, 2 ; Mohammadzadeh R3 ; Sholeh M3 ; Karampoor S4 ; Abdi M3, 5 ; Dogan E6 ; Moghadam MS7 ; Kazemi S1 ; Jalalifar S3 ; Dalir A3 ; Yousefimashouf R1 ; Mirzaei E8 ; Khodavirdipour A9 ; Alikhani MY1
Authors
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Authors Affiliations
  1. 1. Department of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
  2. 2. Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran
  3. 3. Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  5. 5. Student Research Committee, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Basic Biotechnology, Biotechnology Institute, Ankara, Turkey
  7. 7. Department of Microbiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Department of Medical Genetics and Molecular Biology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  9. 9. Division of Humann Genetics, Department of Anatomy, St. John's Hospital, Bangalore, India

Source: Microbial Pathogenesis Published:2020


Abstract

Various bacterial species, previously known as extracellular pathogens, can reside inside different host cells by adapting to intracellular modes by forming microbial aggregates with similar characteristics to bacterial biofilms. Additionally, bacterial invasion of human cells leads to failure in antibiotic therapy, as most conventional anti-bacterial agents cannot reach intracellular biofilm in normal concentrations. Various studies have shown that bacteria such as uropathogenic Escherichia coli, Pseudomonas aeruginosa, Borrelia burgdorferi, Moraxella catarrhalis, non-typeable Haemophilus influenzae, Streptococcus pneumonia, and group A Streptococci produce biofilm-like structures within the host cells. For the first time in this review, we will describe and discuss the new information about intracellular bacterial biofilm formation and its importance in bacterial infectious diseases. © 2020 Elsevier Ltd
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