Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
In Vitro Activity of Nine Antifungal Agents Against a Global Collection of Hortaea Werneckii Isolates, the Agent of Tinea Nigra Publisher Pubmed



Badali H1, 2 ; Alhatmi AMS3, 4, 5 ; Fakhim H6, 7 ; Moghaddasi A1, 8 ; Khodavaisy S9, 10 ; Vaezi A1, 8 ; Ahangarkani F2, 8 ; De Hoog GS3, 5 ; Meis JF5, 11
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  2. 2. Invasive Fungi Research Center, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  3. 3. Westerdijk Fungal Biodiversity Institute, Utrecht, Netherlands
  4. 4. Ministry of Health, Directorate General of Health Services, Ibri, Oman
  5. 5. Centre of Expertise in Mycology, Radboud University Medical Centre/Canisius Wilhelmina Hospital, Nijmegen, Netherlands
  6. 6. Department of Medical Parasitology and Mycology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran
  7. 7. Cellular and Molecular Research Center, Urmia University of Medical Sciences, Urmia, Iran
  8. 8. Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran
  9. 9. Zoonoses Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran
  10. 10. Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  11. 11. Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, Netherlands

Source: International Journal of Antimicrobial Agents Published:2019


Abstract

The in vitro susceptibility of molecularly identified Hortaea werneckii isolates (n = 37), the causative agent of tinea nigra, originating from clinical and environmental sources was determined for nine antifungal agents. Posaconazole had the lowest geometric mean minimum inhibitory concentration (GM MIC) (0.07 µg/mL), followed by voriconazole (0.13 µg/mL), isavuconazole (0.14 µg/mL), itraconazole (0.16 µg/mL), terbinafine (0.19 µg/mL) and amphotericin B (0.92 µg/mL). In contrast, fluconazole (14.56 µg/mL), caspofungin (2.41 µg/mL) and anidulafungin (1.42 µg/mL) demonstrated the highest GM MICs/MECs against H. werneckii. © 2019 Elsevier Ltd
Related Docs
1. The First Report of Tinea Nigra From Iran, New Microbes and New Infections (2022)
Experts (# of related papers)