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In Vitro Combination of Antifungal Drugs With Tacrolimus (Fk506) Holds Promise Against Clinical Candida Species, Including Candida Auris Publisher Pubmed



Khodavaisy S1, 2 ; Gharehbolagh SA1 ; Abdorahimi M3 ; Rezaie S4 ; Ahmadikia K1 ; Badali H5 ; Meis JF6, 7 ; Mahmoudi S8
Authors
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Authors Affiliations
  1. 1. Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Research Center for Antibiotic Stewardship and Antimicrobial Resistance, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Microbiology, Shahr-e-Qods Branch, Islamic Azad University, Tehran, Iran
  4. 4. Department of Chemistry and Biology, Toronto Metropolitan University, Toronto, Canada
  5. 5. Department of Molecular Microbiology & Immunology, South Texas Center for Emerging Infectious Diseases, University of Texas at San Antonio, San Antonio, TX, United States
  6. 6. Center of Expertise in Mycology, Radboud University Medical Centre, Canisius Wilhelmina Hospital, Excellence Center for Medical Mycology of the European Confederation of Medical Mycology (ECMM), Nijmegen, Netherlands
  7. 7. Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, Netherlands
  8. 8. Department of Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

Source: Medical Mycology Published:2023


Abstract

In vitro interactions between tacrolimus, a calcineurin inhibitor, and fluconazole, itraconazole, caspofungin, or anidulafungin were evaluated against Candida auris, C. albicans, C. parapsilosis, and C. glabrata (each five strains). Tacrolimus-itraconazole, tacrolimus-caspofungin, and tacrolimus-fluconazole combinations resulted in synergistic interactions against 95%, 90%, and 60% of Candida isolates, respectively. However, tacrolimus-anidulafungin resulted in only a 35% synergistic effect. A combination of tacrolimus and itraconazole was most potent with synergy against 100% of C. auris, C. parapsilosis, and C. glabrata isolates. Of note, no antagonistic interaction was found. © 2023 The Author(s). Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology.
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