Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
M Eyerozyma Guilliermondii Species Complex: Review of Current Epidemiology, Antifungal Resistance, and Mechanisms Publisher Pubmed



Ghasemi R1 ; Lotfali E2 ; Rezaei K1 ; Madinehzad SA1 ; Tafti MF1 ; Aliabadi N3 ; Kouhsari E4, 5 ; Fattahi M6
Authors
Show Affiliations
Authors Affiliations
  1. 1. Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Department of Medical Parasitology and Mycology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Microbiology Department Islamic, Azad University Tehran Branch, Tehran, Iran
  4. 4. Department of Laboratory Sciences, Faculty of Paramedicine, Golestan University of Medical Sciences, Gorgan, Iran
  5. 5. Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran
  6. 6. Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran

Source: Brazilian Journal of Microbiology Published:2022


Abstract

Meyerozyma guilliermondii has been accepted as a complex composed of Meyerozyma guilliermondii, Meyerozyma carpophila, and Meyerozyma caribbica. M. guilliermondii is a saprophyte detected on human mucosa and skin. It can lead to serious infections in patients with risk factors like chemotherapy, immunodeficiency, gastrointestinal or cardiovascular surgery, and oncology disorders. Most deaths related to M. guilliermondii infections occur in individuals with malignancy. In recent decades, incidence of M. guilliermondii infections is increased. Sensitivity of this microorganism to conventional antifungals (e.g., amphotericin B, fluconazole, micafungin and anidulafungin) was reduced. Prophylactic and empirical uses of these drugs are linked to elevated minimal inhibitory concentrations (MICs) of M. guilliermondii. Drug resistance has concerned many researchers across the world. They are attempting to discover appropriate solution to combat this challenge. This study reviews the most important mechanisms of resistance to antifungals developed by in M. guilliermondii species complex. © 2022, The Author(s) under exclusive licence to Sociedade Brasileira de Microbiologia.
Related Docs
View other Related Docs
1. A Review on Molecular Mechanisms of Antifungal Resistance in Candida Glabrata: Update and Recent Advances, Microbial Drug Resistance (2021)
2. Comparative in Vitro Activities of Seven Antifungal Drugs Against Clinical Isolates of Candida Parapsilosis Complex, Journal de Mycologie Medicale (2020)
3. Species Distribution and Antifungal Susceptibility Profile of Candida Isolates From Blood and Other Normally Sterile Foci From Pediatric Icu Patients in Tehran, Iran, Medical Mycology (2020)
4. Antifungal Susceptibility Testing of Candida Species Isolated From the Immunocompromised Patients Admitted to Ten University Hospitals in Iran: Comparison of Colonizing and Infecting Isolates, BMC Infectious Diseases (2017)
5. Candidemia in Children Caused by Uncommon Species of Candida, Archives of Pediatric Infectious Diseases (2018)
6. Clinical, Epidemiological, and Mycological Features of Patients With Candidemia: Experience in Two Tertiary Referral Centers in Iran, Current Medical Mycology (2022)
7. Frequency of Uncommon Clinical Yeast Species Confirmed by Its-Sequencing, Archives of Clinical Infectious Diseases (2019)
8. Low Level of Antifungal Resistance of Candida Glabrata Blood Isolates in Turkey: Fluconazole Minimum Inhibitory Concentration and Fks Mutations Can Predict Therapeutic Failure, Mycoses (2020)
Experts (# of related papers)
View all Related Experts
Sadegh Khodavaisy (14)
Mohammadreza Salehi (10)
Other Related Docs
9. Epidemiology of Yeast Species Causing Bloodstream Infection in Tehran, Iran (2015-2017); Superiority of 21-Plex Pcr Over the Vitek 2 System for Yeast Identification, Journal of Medical Microbiology (2020)
10. South Asian (Clade I) Candida Auris Meningitis in a Paediatric Patient in Iran With a Review of the Literature, Mycoses (2022)
11. Identification of Uncommon Oral Yeasts From Cancer Patients by Maldi-Tof Mass Spectrometry, BMC Infectious Diseases (2018)
12. Exploring the Diversity Of Uncommon Oral Yeast Species And Associated Risk Factors Among Substance Abusers In Southwestern Iran, Scientific Reports (2024)
13. Microbial Epidemiology of Candidaemia in Neonatal and Paediatric Intensive Care Units at the Children's Medical Center, Tehran, Mycoses (2018)
14. Virulence Factors and Azole-Resistant Mechanism of Candida Tropicalis Isolated From Candidemia, Mycopathologia (2021)
15. The First Case of Wickerhamomyces Anomalus Fungemia in Iran in an Immuneodeficient Child, a Review on the Literature, Journal of Medical Mycology (2023)
16. Caspofungin-Non-Susceptible Candida Orthopsilosis Isolated From Onychomycosis in Iran, Iranian Journal of Public Health (2017)
17. Contamination of Cockroaches (Insecta: Blattaria) to Medically Fungi: A Systematic Review and Meta-Analysis, Journal de Mycologie Medicale (2017)
18. Candida Auris, an Emerging Fungal Pathogen, Journal of Mazandaran University of Medical Sciences (2019)
19. A Comprehensive Review of Identification Methods for Pathogenic Yeasts: Challenges and Approaches, Advanced Biomedical Research (2023)
20. Fungal Keratitis: An Overview of Clinical and Laboratory Aspects, Mycoses (2018)
21. Evaluation of Virulence Factors and Azole Resistance Mechanisms of Candida Tropicalis Isolates From Head and Neck Cancer Patients With Opc, Iranian Journal of Microbiology (2023)
22. Epidemiological Features of Nosocomial Candidaemia in Neonates, Infants and Children: A Multicentre Study in Iran, Mycoses (2020)
23. Drug Susceptibility Pattern of Candida Species Isolated From Skin of Neonates to Fluconazole, Amphotericin B and Caspofungin, Tehran University Medical Journal (2017)
24. The Relationship Between Biofilm Formation and Mortality in Patients With Candida Tropicalis Candidemia, Microbial Pathogenesis (2021)
25. Low Level of Antifungal Resistance in Iranian Isolates of Candida Glabrata Recovered From Blood Samples in a Multicenter Study From 2015 to 2018 and Potential Prognostic Values of Genotyping and Sequencing of Pdr1, Antimicrobial Agents and Chemotherapy (2019)
26. Multiplex Size Marker (Yeast Plex) for Rapid and Accurate Identification of Pathogenic Yeasts, Journal of Clinical Laboratory Analysis (2022)
27. Candidemia Among Hospitalized Pediatric Patients Caused by Several Clonal Lineages of Candida Parapsilosis, Journal of Fungi (2022)
28. Five-Year Laboratory-Based Study of Candida Albicans Versus Non-Albicans Candida Species at a Tertiary Pediatric Care Hospital in Iran, Kuwait Medical Journal (2020)
29. Incidence and Spectrum of Yeast Species Isolated From the Oral Cavity of Iranian Patients Suffering From Hematological Malignancies, Journal of Oral Microbiology (2019)
30. Molecular Diagnosis, Phylogenetic Analysis, and Antifungal Susceptibility Profiles of Candida Species Isolated From Neutropenic Oncological Patients, BMC Infectious Diseases (2023)
31. In Vitro Synergy of Echinocandins With Triazoles Against Fluconazole-Resistant Candida Parapsilosis Complex Isolates, Journal of Global Antimicrobial Resistance (2020)
32. In Vitro Activity of Caspofungin Against Fluconazole-Resistant Candida Species Isolated From Clinical Samples in Iran, Jundishapur Journal of Microbiology (2015)
33. Evaluation of Molecular Epidemiology, Clinical Characteristics, Antifungal Susceptibility Profiles, and Molecular Mechanisms of Antifungal Resistance of Iranian Candida Parapsilosis Species Complex Blood Isolates, Frontiers in Cellular and Infection Microbiology (2020)
34. Antifungal Susceptibility, Genotyping, Resistance Mechanism, and Clinical Profile of Candida Tropicalis Blood Isolates, Medical Mycology (2020)
35. Intravenous Catheter-Associated Candidemia Due to Candida Membranaefaciens: The First Iranian Case, Journal of Tehran University Heart Center (2015)
36. Unequivocal Identification of an Underestimated Opportunistic Yeast Species, Cyberlindnera Fabianii, and Its Close Relatives Using a Dual-Function Pcr and Literature Review of Published Cases, Medical Mycology (2019)
37. Candida Palmioleophila Candidemia and Bacterial Co-Infection in a 3-Month-Old Infant With Biliary Atresia, Frontiers in Cellular and Infection Microbiology (2023)
38. Analysis of Molecular Resistance to Azole and Echinocandin in Candida Species in Patients With Vulvovaginal Candidiasis, Current Medical Mycology (2022)