Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Effects of Exercise Training on Inflammatory Biomarkers in Patients With Breast Cancer: A Systematic Review and Meta-Analysis Publisher Pubmed



Abbasi F1 ; Pourjalali H1 ; Do Nascimento IJB2, 3 ; Zargarzadeh N4 ; Mousavi SM5 ; Eslami R1 ; Milajerdi A6
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Exercise Physiology, Faculty of Physical Education and Sports Sciences, Allameh Tabataba'i University, Tehran, Iran
  2. 2. School of Medicine, Medical College of Wisconsin, Milwaukee, WI, United States
  3. 3. University Hospital and School of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
  4. 4. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran

Source: Cytokine Published:2022


Abstract

Objective: Despite several studies on the effects of exercise training on inflammatory biomarkers in patients with breast cancer, no earlier study has systematically summarized their findings. Current systematic review and meta-analysis has been done on earlier clinical trials in this topic. Method: Relevant studies published up to August 2021 were searched through PubMed, MEDLINE, SCOPUS, EMBASE, and Google Scholar using predefined keywords. Studies that examined the effect of exercise training on inflammatory biomarkers in adult women with breast cancer were included. Result: A total of 18 studies were included. Combining 11 effect sizes, exercise training significantly reduced CRP level (WMD: −0.55; 95% CI: −1.10, −0.01). However, it had no significant influence on serum TNF-α (WMD: −0.40; 95% CI: −1.30, 0.50) and IL-6 concentrations (WMD: −0.05, 95% CI: −0.53, 0.43) in 8 and 15 studies, respectively. Pooling 7 effect sizes, we failed to find significant changes in IL-8 following exercise training (WMD: −0.65, 95% CI: −1.57, 0.28). Moreover, we reached no significant findings for serum levels of INF-ɣ (WMD: −2.66, 95% CI: −7.67, 2.36), IL-1β (WMD: 0.03, 95% CI: −0.26, 0.21), and IL-10 (WMD: −0.70, 95% CI: −2.92, 1.52). Based on subgroup analyses, best findings were reached in long-term intervention and after concurrent training. Discussion: Chronic inflammation is hypothesized to be associated with breast cancer development. We found significant reduction in CRP level following exercise training, which was more considerable after concurrent aerobic and resistance training and in long-term intervention. No significant changes were seen in serum levels of TNF-α, IL-6, IL-8, IL-10, INF-ɣ, IL-1β following exercise training. Further studies are needed to find more details. © 2021 Elsevier Ltd
Related Docs
1. The Effect of Exercise Training on Serum Glucose and Lipid Profiles in Patients With Breast Cancer: A Systematic Review and Meta-Analysis of Randomized Clinical Trials, Journal of Physical Activity and Health (2021)
2. The Effects of High-Intensity Interval Training Vs. Moderate-Intensity Continuous Training on Inflammatory Markers, Body Composition, and Physical Fitness in Overweight/Obese Survivors of Breast Cancer: A Randomized Controlled Clinical Trial, Cancers (2021)
3. High-Intensity Interval Training Can Modulate the Systemic Inflammation and Hsp70 in the Breast Cancer: A Randomized Control Trial, Journal of Cancer Research and Clinical Oncology (2019)
4. Combined Effect of Aerobic Interval Training and Selenium Nanoparticles on Expression of Il-15 and Il-10/Tnf-Α Ratio in Skeletal Muscle of 4T1 Breast Cancer Mice With Cachexia, Cytokine (2017)
5. The Immunoemotional Regulatory System, Biophysics and Neurophysiology of the Sixth Sense (2019)
6. Inverse Association of Long-Term Nut Consumption With Weight Gain and Risk of Overweight/Obesity: A Systematic Review, Nutrition Research (2019)
Experts (# of related papers)
View all Related Experts
Nima Rezaei (1)
Alimohammad Alizadeh (1)