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Exercise-Induced Modulation of Monocytes in Breast Cancer Survivors Publisher



Khosravi N1, 2 ; Hanson ED1, 3 ; Farajivafa V1, 2 ; Evans WS1 ; Lee JT1 ; Danson E1 ; Wagoner CW1 ; Harrell EP1 ; Sullivan SA1 ; Nyrop KA3, 4 ; Muss HB3, 4 ; Bartlett DB5 ; Jensen BC6 ; Haghighat S7 Show All Authors
Authors
  1. Khosravi N1, 2
  2. Hanson ED1, 3
  3. Farajivafa V1, 2
  4. Evans WS1
  5. Lee JT1
  6. Danson E1
  7. Wagoner CW1
  8. Harrell EP1
  9. Sullivan SA1
  10. Nyrop KA3, 4
  11. Muss HB3, 4
  12. Bartlett DB5
  13. Jensen BC6
  14. Haghighat S7
  15. Shamsi MM2
  16. Battaglini CL1, 3
Show Affiliations
Authors Affiliations
  1. 1. Department of Exercise & Sport Science, Exercise Oncology Research Laboratory, University of North Carolina, Chapel Hill, NC, United States
  2. 2. Physical Education & Sport Sciences Department, Faculty of Humanities, Tarbiat Modares University, Tehran, Iran
  3. 3. Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, United States
  4. 4. Department of Hematology Oncology University of North Carolina, Chapel Hill, NC, United States
  5. 5. Department of Medicine, Duke University, Durham, NC, United States
  6. 6. Division of Cardiology, University of North Carolina, Chapel Hill, NC, United States
  7. 7. Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran

Source: Brain# Behavior# and Immunity - Health Published:2021


Abstract

Background: Exercise training reduces inflammation in breast cancer survivors; however, the mechanism is not fully understood. Objectives: The effects of acute and chronic exercise on monocyte toll-like receptor (TLR2 and 4) expression and intracellular cytokine production were examined in sedentary breast cancer survivors. Methods: Eleven women with stage I, II, or III breast cancer within one year of treatment completion performed an acute, intermittent aerobic exercise trial. Blood samples were obtained before, immediately, and 1 h after a 45-min acute exercise trial that was performed before and after 16 weeks of combined aerobic and resistance. LPS-stimulated intracellular IL-1ß, TNF, and IL-6 production, and TLR2 and TLR4 expression were evaluated in CD14+CD16- and CD14+CD16+ monocytes using flow cytometry. Results: Exercise training decreased IL-1ß+CD14+CD16- proportion (24.6%, p=0.016), IL-1ß+CD14+CD16- mean fluorescence intensity (MFI) (−9989, p=0.014), IL-1ß+CD14+CD16+ MFI (−11101, p=0.02), and IL-6+CD14+CD16- proportion (16.9%, P=0.04). TLR2 and TLR4 expression did not change following exercise training but decreased 1 h after acute exercise in CD14+CD16- (−63, p=0.002) and CD14+CD16+ (−18, p=0.006) monocytes, respectively. Immediately after the acute exercise, both monocyte subgroup cell concentration increased, with CD14+CD16+ concentrations being decreased at 1 h post without changes in intracellular cytokine production. Conclusions: Exercise training reduced monocyte intracellular pro-inflammatory cytokine production, especially IL-1ß, although these markers did not change acutely. While acute exercise downregulated the expression of TLR2 and TLR4 on monocytes, this was not sustained over the course of training. These results suggest that the anti-inflammatory effect of combined aerobic and resistance exercise training in breast cancer survivors may be, in part, due to reducing resting monocyte pro-inflammatory cytokine production. © 2021
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