Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Survey on Interaction Between Nutrient Status and Selected Polymorphisms in Association With Weight Loss of Patients With Severe Obesity Underwent Bariatric Surgery Publisher Pubmed



Cheraghi S1 ; Taheri G2 ; Safari S3 ; Bakhshandeh H4 ; Malek M5 ; Moghimian B1 ; Mottaghi A1, 5
Authors

Source: Obesity Surgery Published:2024


Abstract

Background: There is little information about the effect of single nucleotide polymorphisms (SNP) and nutritional status and weight loss after bariatric surgery. This study investigated the interactive effect of eight obesity-related SNPs and nutritional status on weight loss after Roux-en-Y gastric bypass (RYGB). Method: This is a case–control study. After 1-year follow-up, the patients who underwent RYGB were dividing into two groups. The case group consisted of patients who lost more than 50% of their excess body weight (EBW%) 1 year after the surgery. The control group included patients who lost < 50% of EBW at same time frame. Then, the relationship between eight SNPs related to UCP2, FTO, LEPR, GHRL, and NPY genes with weight loss were checked. Results: In this study, 160 patients were recruited. The median of age for case and control group were 43 and 42 respectively. The presence of mutant variant NPYrs16147 had a significant relationship in terms of weight loss between the two groups (P > 0.05). In dominant model, two SNPs, UCP2 rs659366 and UCP2 rs660339, showed protective effect of the vitamin D deficiency. Conclusion: In conclusion, the presence mutant variant of NPYrs16147 is directly related to the incidence of weight loss greater than 50% of EBW. However, it is apparent individual behavioral, dietary, and other factors may have more influence on weight loss among patients underwent RYGB. Graphical Abstract: (Figure presented.) © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.
Related Docs
View other Related Docs
1. Comparison of Energy and Food Intake Between Gastric Bypass and Sleeve Gastrectomy: A Meta-Analysis and Systematic Review, Obesity Surgery (2019)
2. Long-Term Systemic Effects of Metabolic Bariatric Surgery: A Multidisciplinary Perspective, Heliyon (2024)
3. Excessive Weight Loss After Bariatric Surgery: A Prediction Model Retrospective Cohort Study, Updates in Surgery (2022)
Experts (# of related papers)
View all Related Experts
Gholamreza Mohammadi Farsani (4)
Kurosh Djafarian (3)
Other Related Docs
4. Changes in Body Composition, Dietary Intake, and Substrate Oxidation in Patients Underwent Laparoscopic Roux-En-Y Gastric Bypass and Laparoscopic Sleeve Gastrectomy: A Comparative Prospective Study, Obesity Surgery (2019)
5. Role of Rs9939506 Polymorphism of Fto Gene in Resistance to Eating in Male Adolescents, BMC Pediatrics (2023)
6. The Effects of Protein Supplementation on Body Composition After Bariatric Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Obesity (2025)
7. Association Between Dietary Intake After Roux-En-Y Gastric Bypass Surgery and Antioxidant/Inflammatory Status: A 6-Month Pilot Prospective Cohort Study, Obesity Surgery (2024)
8. Influence of Gastric Bypass Surgery on Resting Energy Expenditure, Body Composition, Physical Activity, and Thyroid Hormones in Morbidly Obese Patients, Diabetes# Metabolic Syndrome and Obesity (2018)
9. Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1Α Variation: A Closer Look at Obesity Onset Age and Its Related Metabolic Status and Body Composition, Applied Physiology# Nutrition and Metabolism (2018)
10. Short-Term Changes on Body Composition After Sleeve Gastrectomy and One Anastomosis Gastric Bypass, Journal of Laparoendoscopic and Advanced Surgical Techniques (2022)
11. Predictive Value of Complete Blood Count (Cbc)-Derived Indices—C-Reactive-Protein-Albumin-Lymphocyte Index (Cally), Glucose-To-Lymphocyte Ratio (Glr), Prognostic Nutritional Index (Pni), Hemoglobin, Albumin, Lymphocyte, Platelet (Halp), and Controlling Nutritional Status (Count)—On Body Composition Changes After Bariatric Surgery, Obesity Surgery (2025)
12. Changes in Fat Mass Index and Fat-Free Mass Index Vary Significantly by Age and Sex of the Patient, and by Type of Bariatric Surgery, Obesity Surgery (2024)
13. Association Between Peroxisome Proliferator Activated Receptor Gamma Coactivator 1 Gene With Overweight and Obesity Risk: Case–Control Study and Meta-Analysis, Human Gene (2022)
14. Efficacy of a Comprehensive Weight Reduction Intervention in Male Adolescents With Different Fto Genotypes, Endocrinology# Diabetes and Metabolism (2024)
15. Effect of Different Bariatric Surgery Methods on Metabolic Syndrome in Patients With Severe Obesity, Updates in Surgery (2024)
16. Comparative Study of Resting Metabolic Rate and Plasma Amino Acid Profile in Patients Who Underwent Laparoscopic Roux-En-Y Gastric Bypass and Laparoscopic Sleeve Gastrectomy: 6-Month Follow-Up Study, Obesity Surgery (2019)
17. One Anastomosis Gastric Bypass Surgery in Type2 Diabetes Patients With Body Mass Index < 35 Kg/M2: A Multi-Center Retrospective Cohort Study, Annals of Medicine and Surgery (2022)
18. Energy Expenditure Related Biomarkers Following Bariatric Surgery: A Prospective Six-Month Cohort Study, BMC Surgery (2024)
19. The Impact of Bariatric Surgery Procedures on the Modulation of Cardiometabolic Risk Factors in Patients With Severe Obesity: A 12-Month Follow-Up, Journal of International Medical Research (2022)
20. Dietary Glycemic Index and Glycemic Load Mediate the Effect of Cartpt Rs2239670 Gene Polymorphism on Metabolic Syndrome and Metabolic Risk Factors Among Adults With Obesity, BMC Endocrine Disorders (2022)