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Microfluidic Platform With Integrated Electrical Actuator to Enrich and Locating Atypical/Cancer Cells From Liquid Cytology Samples Publisher



Jahangiri M1 ; Khosravi S1 ; Moghtaderi H1 ; Ranjbar M1 ; Abadijoo H1 ; Sarmadi S2 ; Izadimood N2 ; Shirali E3 ; Hoseinpour P4 ; Gity M5, 6 ; Abbasvandi F7 ; Mohajerzadeh L8 ; Aghdam MK9 ; Abdolahad M1
Authors
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Authors Affiliations
  1. 1. Nano Electronic Center of Excellence, Nano Bio Electronic Devices Lab., School of Electrical and Computer Engineering, Faculty of Engineering, University of Tehran, Tehran, 14395/515, Iran
  2. 2. Department of Pathology, Yas Hospital, Tehran University of Medical Sciences, P.O. Box 14155/6447, Tehran, Iran
  3. 3. Gynecology Department, Yas Hospital, Tehran University of Medical Sciences, P.O. Box 14155/6447, Tehran, Iran
  4. 4. Central Lab of Breast Pathobiology, SEPAS Lab, Tehran, Iran
  5. 5. Advanced Diagnostic and Interventional Radiology Research Center, Tehran University of Medical Sciences, P.O. Box 14155/6447, Tehran, Iran
  6. 6. Department of Radiology, Medical Imaging Center, Tehran University of Medical Sciences, P.O. Box 14155/6447, Tehran, Iran
  7. 7. Clinic of Surgery, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, P.O. Box 15179/64311, Tehran, Iran
  8. 8. Pediatric Surgery Research Center, Research Institute for Children Health, Shahid Beheshti University of Medical Sciences, P.O. Box. 19395-4719, Tehran, Iran
  9. 9. Pediatric Pathology Research Center, Research Institute for Children Health, Shahid Beheshti University of Medical Sciences, P.O. Box. 19395-4719, Tehran, Iran

Source: Sensors and Actuators# B: Chemical Published:2019


Abstract

A microfluidic electrical actuator in the form of a cytological slide has been developed to separate and relocate atypical/cancer cells of liquid cytology samples (such as fine needle aspiration, uterine cervical smear and bone marrow aspiration) in a limited space for fast and precise pathological evaluation. The mechanism of this system named smart cytological slide (SCS) was based on the tendency of atypical/neoplastic cells, which have significant negative membrane charges, to positive pole region of direct electric field applied by the patterned gold microelectrodes of the actuator. Results of SCS on cytological samples of 70 patients showed better separating profile with much greater efficacy and selectivity than conventional cytological slides (CCS). Moreover, SCS detected the false negative responses of CCS in 5% of the samples while we used from the residues of the samples in SCS tests. © 2019 Elsevier B.V.
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