A Human Pilot Study on Positive Electrostatic Charge Effects in Solid Tumors of the Late-Stage Metastatic Patients

A Human Pilot Study on Positive Electrostatic Charge Effects in Solid Tumors of the Late-Stage Metastatic Patients Publisher

Zandi A^{1, 2} ; Shojaeian F^{1, 3} ; Abbasvandi F^{4, 5} ; Faranoush M^{6, 7} ; Anbiaee R⁸ ; Hoseinpour P^{1, 9} ; Gilani A¹ ; Saghafi M¹ ; Zandi A^{1, 2} ; Hoseinyazdi M¹¹ ; Davari Z¹ ; Miraghaie SH¹ ; Tayebi M⁴ ; Taheri MS¹² Show All Authors

Zandi A^{1, 2}
Shojaeian F^{1, 3}
Abbasvandi F^{4, 5}
Faranoush M^{6, 7}
Anbiaee R⁸
Hoseinpour P^{1, 9}
Gilani A¹
Saghafi M¹
Zandi A^{1, 2}
Hoseinyazdi M¹¹
Davari Z¹
Miraghaie SH¹
Tayebi M⁴
Taheri MS¹²
Ardestani SMS¹³
Sheikhi Mobarakeh Z¹⁴
Nikshoar MR¹⁵
Enjavi MH^{1, 2}
Kordehlachin Y¹
Mousavikiasary SMS¹
Mamdouh A¹
Akbari ME⁵
Yunesian M^{16, 17}
Abdolahad M^{1, 2, 18, 19}

Show Affiliations

1. Nano Electronic Centre of Excellence, Nanobioelectronic Devices Laboratory, Cancer Electronics Research Group, School of Electrical and Computer Engineering, Faculty of Engineering, University of Tehran, Tehran, Iran
2. Nano Electronic Centre of Excellence, Nanoelectronics and Thin Film Laboratory, School of Electrical and Computer Engineering, Faculty of Engineering, University of Tehran, Tehran, Iran
3. School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4. Department of ATMP, Breast Cancer Research Centre, Motamed Cancer Institute, ACECR, Tehran, Iran
5. Cancer Research Centre, Shahid Beheshti University of Medical Sciences, Tehran, Iran
6. Pediatric Growth and Development Research Centre, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran
7. Cardio-Oncology Research Centre, Rajaie Cardiovascular Medical and Research Centre, Iran University of Medical Sciences, Tehran, Iran
8. Department of Radiation Oncology, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
9. SEPAS Pathology Laboratory, Tehran, Iran
10. Department of Otolaryngology, Head and Neck Surgery, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
11. Medical Imaging Research Centre, Shiraz University of Medical Sciences, Shiraz, Iran
12. Department of Radiology, Shohada Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
13. Department of Psychiatry, Behavioural Sciences Research Centre, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
14. Department of Quality of Life, Breast Cancer Research Centre, Motamed Cancer Institute, ACECR, Tehran, Iran
15. Department of Gastroenterology Surgery, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
16. Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
17. Department of Research Methodology and Data Analysis, Institute for Environmental Research, Tehran University of Medical Sciences, Tehran, Iran
18. Imam-Khomeini Hospital, Tehran University of Medical Sciences, Cancer Institute, Tehran, Iran
19. UT&TUMS Cancer Electrotechnique Research Centre, YAS Hospital, Tehran, Iran

Source: Frontiers in Medicine Published:2023

Abstract

Background: Correlative interactions between electrical charges and cancer cells involve important unknown factors in cancer diagnosis and treatment. We previously reported the intrinsic suppressive effects of pure positive electrostatic charges (PEC) on the proliferation and metabolism of invasive cancer cells without any effect on normal cells in cell lines and animal models. The proposed mechanism was the suppression of pro-caspases 3 and 9 with an increase in Bax/Bcl2 ratio in exposed malignant cells and perturbation induced in the KRAS pathway of malignant cells by electrostatic charges due to the phosphate molecule electrostatic charge as the trigger of the pathway. This study aimed to examine PECs as a complementary treatment for patients with different types of solid metastatic tumors, who showed resistance to chemotherapy and radiotherapy. Methods: In this study, solid metastatic tumors of the end-stage patients (n = 41) with various types of cancers were locally exposed to PEC for at least one course of 12 days. The patient’s signs and symptoms, the changes in their tumor size, and serum markers were followed up from 30 days before positive electrostatic charge treating (PECT) until 6 months after the study. Results: Entirely, 36 patients completed the related follow-ups. Significant reduction in tumor sizes and cancer-associated enzymes as well as improvement in cancer-related signs and symptoms and patients’ lifestyles, without any side effects on other tissues or metabolisms of the body, were observed in more than 80% of the candidates. Conclusion: PECT induced significant cancer remission in combination with other therapies. Therefore, this non-ionizing radiation would be a beneficial complementary therapy, with no observable side effects of ionizing radiotherapy, such as post-radiation inflammation. Copyright © 2023 Zandi, Shojaeian, Abbasvandi, Faranoush, Anbiaee, Hoseinpour, Gilani, Saghafi, Zandi, Hoseinyazdi, Davari, Miraghaie, Tayebi, Taheri, Ardestani, Sheikhi Mobarakeh, Nikshoar, Enjavi, Kordehlachin, Mousavi-kiasary, Mamdouh, Akbari, Yunesian and Abdolahad.

2. Smartphone-Based Device for Point-Of-Care Diagnostics of Pulmonary Inflammation Using Convolutional Neural Networks (Cnns), Scientific Reports (2024)

3. Microfluidic Platform With Integrated Electrical Actuator to Enrich and Locating Atypical/Cancer Cells From Liquid Cytology Samples, Sensors and Actuators# B: Chemical (2019)

4. Breast Cancer Diagnostics by the Intelligent Analysis of White Blood Cells’ Interaction With Target Cancer Cells Using Convolutional Neural Networks, Microchemical Journal (2024)

5. Healing Field: Using Alternating Electric Fields to Prevent Cytokine Storm by Suppressing Clonal Expansion of the Activated Lymphocytes in the Blood Sample of the Covid-19 Patients, Frontiers in Bioengineering and Biotechnology (2022)

6. Evaluation of the Effect of Electron Beam Therapy on Oxidative Stress and Some Minerals in Patients With Type 2 Diabetes Mellitus, Functional Food Science (2022)

7. Capture-Free Deactivation of Ctcs in the Bloodstream; a Metastasis Suppression Method by Electrostatic Stimulation of the Peripheral Blood, Biosensors and Bioelectronics (2021)

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Style	Citing Format
MLA	Zandi A, et al.. "A Human Pilot Study on Positive Electrostatic Charge Effects in Solid Tumors of the Late-Stage Metastatic Patients." Frontiers in Medicine, vol. 10, no. , 2023, pp. -.
APA	Zandi A, Shojaeian F, Abbasvandi F, Faranoush M, Anbiaee R, Hoseinpour P, Gilani A, Saghafi M, Zandi A, Hoseinyazdi M, Davari Z, Miraghaie SH, Tayebi M, Taheri MS, Ardestani SMS, Sheikhi Mobarakeh Z, Nikshoar MR, Enjavi MH, Kordehlachin Y, ... Abdolahad M (2023). A Human Pilot Study on Positive Electrostatic Charge Effects in Solid Tumors of the Late-Stage Metastatic Patients. Frontiers in Medicine, 10(), -.
Chicago	Zandi A, Shojaeian F, Abbasvandi F, Faranoush M, Anbiaee R, Hoseinpour P, Gilani A, et al.. "A Human Pilot Study on Positive Electrostatic Charge Effects in Solid Tumors of the Late-Stage Metastatic Patients." Frontiers in Medicine 10, no. (2023): -.
Harvard	Zandi A et al. (2023) 'A Human Pilot Study on Positive Electrostatic Charge Effects in Solid Tumors of the Late-Stage Metastatic Patients', Frontiers in Medicine, 10(), pp. -.
Vancouver	Zandi A, Shojaeian F, Abbasvandi F, Faranoush M, Anbiaee R, Hoseinpour P, et al.. A Human Pilot Study on Positive Electrostatic Charge Effects in Solid Tumors of the Late-Stage Metastatic Patients. Frontiers in Medicine. 2023;10():-.
BibTex	@article{ author = {Zandi A and Shojaeian F and Abbasvandi F and Faranoush M and Anbiaee R and Hoseinpour P and Gilani A and Saghafi M and Zandi A and Hoseinyazdi M and Davari Z and Miraghaie SH and Tayebi M and Taheri MS and Ardestani SMS and Sheikhi Mobarakeh Z and Nikshoar MR and Enjavi MH and Kordehlachin Y and Mousavikiasary SMS and Mamdouh A and Akbari ME and Yunesian M and Abdolahad M}, title = {A Human Pilot Study on Positive Electrostatic Charge Effects in Solid Tumors of the Late-Stage Metastatic Patients}, journal = {Frontiers in Medicine}, volume = {10}, number = {}, pages = {-}, year = {2023} }
RIS	TY - JOUR AU - Zandi A AU - Shojaeian F AU - Abbasvandi F AU - Faranoush M AU - Anbiaee R AU - Hoseinpour P AU - Gilani A AU - Saghafi M AU - Zandi A AU - Hoseinyazdi M AU - Davari Z AU - Miraghaie SH AU - Tayebi M AU - Taheri MS AU - Ardestani SMS AU - Sheikhi Mobarakeh Z AU - Nikshoar MR AU - Enjavi MH AU - Kordehlachin Y AU - Mousavikiasary SMS AU - Mamdouh A AU - Akbari ME AU - Yunesian M AU - Abdolahad M TI - A Human Pilot Study on Positive Electrostatic Charge Effects in Solid Tumors of the Late-Stage Metastatic Patients JO - Frontiers in Medicine VL - 10 IS - SP - EP - PY - 2023 ER -

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