Capture-Free Deactivation of Ctcs in the Bloodstream; a Metastasis Suppression Method by Electrostatic Stimulation of the Peripheral Blood

Capture-Free Deactivation of Ctcs in the Bloodstream; a Metastasis Suppression Method by Electrostatic Stimulation of the Peripheral Blood Publisher Pubmed

Ghaderinia M¹ ; Khayamian MA¹ ; Abadijoo H¹ ; Shalileh S¹ ; Faramarzpour M¹ ; Zandi A¹ ; Simaee H^{1, 2} ; Abbasvandi F^{1, 3} ; Esmailinejad MR⁴ ; Rafizadehtafti S¹ ; Jahangiri M¹ ; Kordehlachin Y¹ ; Ghaffari H¹ ; Ansari E⁵ Show All Authors

Ghaderinia M¹
Khayamian MA¹
Abadijoo H¹
Shalileh S¹
Faramarzpour M¹
Zandi A¹
Simaee H^{1, 2}
Abbasvandi F^{1, 3}
Esmailinejad MR⁴
Rafizadehtafti S¹
Jahangiri M¹
Kordehlachin Y¹
Ghaffari H¹
Ansari E⁵
Dabbagh N⁶
Akbari ME⁶
Hoseinpour P⁷
Abdolahad M^{1, 8, 9}

Show Affiliations

1. Nano Electronic Center of Excellence, Nano Bio Electronic Devices Lab, School of Electrical and Computer Engineering, University of Tehran, P.O. Box 14395/515, Tehran, Iran
2. Integrative Oncology Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, P.O. BOX 15179/64311, Tehran, Iran
3. ATMP Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, P.O. BOX 15179/64311, Tehran, Iran
4. Department of Surgery and Radiology, Faculty of Veterinary Medicine, University of Tehran, P.O. Box 14155/6453, Tehran, Iran
5. Nano Electronic Center of Excellence, Thin Film and Nano Electronics Lab, School of Electrical and Computer Engineering, University of Tehran, P.O. Box 14395/515, Tehran, Iran
6. Cancer Research Center, Shahid Beheshti University of Medical Sciences, P.O. BOX 15179/64311, Tehran, Iran
7. SEPAS Pathology Lab, P.O.BOX 1991945391, Tehran, Iran
8. Cancer Institute, Imam-Khomeini Hospital, Tehran University of Medical Sciences, P.O. BOX 13145-158, Tehran, Iran
9. UT&TUMS Cancer Electrotechnique Research Center, YAS Hospital, P.O. Box 1598718311, Tehran, Iran

Source: Biosensors and Bioelectronics Published:2021

Abstract

While limited investigations have been reported on CTC elimination and its profits, recently, some new works were reported on detection followed by the destruction of CTCs. Limitations and complications of CTC capturing procedures have highly reduced the chance of selective destruction of CTCs in the bloodstream in the therapeutic guidelines of the patients. Here, we selectively deactivated the invasive function of CTCs during their circulation in the bloodstream by exposing the whole blood to pure positive electrostatic charge stimulation (PPECS). Our treatment suppressed pulmonary metastasis and extended the survival of the mice had been intravenously injected by electrostatically deactivated 4T1 breast cancer CTCs. Moreover, the number of cancerous lung nodules was drastically reduced in the mice injected by treated CTCs in comparison with the non-treated cohort. Evaluating the side effect of the PPECS on the blood components revealed no major effect on the functional properties of the white blood cells, and just a negligible fraction (∼10%) was damaged during this process. This approach does not need any capturing or targeting of CTCs from the blood as it is focused on perturbing the electrical function of negatively-charged tumor cells after being exposed to positive electrostatic charges. Taken together, continuous in-vivo deactivation of CTCs by PPECS with no requirement to complicated capturing protocols may improve the survival of cancer patients. © 2021 Elsevier B.V.

Related Docs

View other Related Docs

1. Healing Field: Using Alternating Electric Fields to Prevent Cytokine Storm by Suppressing Clonal Expansion of the Activated Lymphocytes in the Blood Sample of the Covid-19 Patients, Frontiers in Bioengineering and Biotechnology (2022)

2. Prognostic and Therapeutic Significance of Circulating Tumor Cells in Patients With Lung Cancer, Cellular Oncology (2020)

3. Hydroelectric Actuator for 3-Dimensional Analysis of Electrophoretic and Dielectrophoretic Behavior of Cancer Cells; Suitable in Diagnosis and Invasion Studies, Biomaterials Advances (2023)

4. Breast Cancer Diagnostics by the Intelligent Analysis of White Blood Cells’ Interaction With Target Cancer Cells Using Convolutional Neural Networks, Microchemical Journal (2024)

5. Positive Electrostatic Therapy of Metastatic Tumors: Selective Induction of Apoptosis in Cancer Cells by Pure Charges, Cancer Medicine (2021)

6. Microfluidic Platform With Integrated Electrical Actuator to Enrich and Locating Atypical/Cancer Cells From Liquid Cytology Samples, Sensors and Actuators# B: Chemical (2019)

7. Carbon Nanotube Based Dielectric Spectroscopy of Tumor Secretion; Electrochemical Lipidomics for Cancer Diagnosis, Biosensors and Bioelectronics (2019)

8. A Micropillar Array-Based Microfluidic Chip for Label-Free Separation of Circulating Tumor Cells: The Best Micropillar Geometry?, Journal of Advanced Research (2023)

Experts (# of related papers)

View all Related Experts

Masoumeh Gity (2)

Soheila Sarmadi (1)

Style	Citing Format
MLA	Ghaderinia M, et al.. "Capture-Free Deactivation of Ctcs in the Bloodstream; a Metastasis Suppression Method by Electrostatic Stimulation of the Peripheral Blood." Biosensors and Bioelectronics, vol. 183, no. , 2021, pp. -.
APA	Ghaderinia M, Khayamian MA, Abadijoo H, Shalileh S, Faramarzpour M, Zandi A, Simaee H, Abbasvandi F, Esmailinejad MR, Rafizadehtafti S, Jahangiri M, Kordehlachin Y, Ghaffari H, Ansari E, Dabbagh N, Akbari ME, Hoseinpour P, Abdolahad M (2021). Capture-Free Deactivation of Ctcs in the Bloodstream; a Metastasis Suppression Method by Electrostatic Stimulation of the Peripheral Blood. Biosensors and Bioelectronics, 183(), -.
Chicago	Ghaderinia M, Khayamian MA, Abadijoo H, Shalileh S, Faramarzpour M, Zandi A, Simaee H, et al.. "Capture-Free Deactivation of Ctcs in the Bloodstream; a Metastasis Suppression Method by Electrostatic Stimulation of the Peripheral Blood." Biosensors and Bioelectronics 183, no. (2021): -.
Harvard	Ghaderinia M et al. (2021) 'Capture-Free Deactivation of Ctcs in the Bloodstream; a Metastasis Suppression Method by Electrostatic Stimulation of the Peripheral Blood', Biosensors and Bioelectronics, 183(), pp. -.
Vancouver	Ghaderinia M, Khayamian MA, Abadijoo H, Shalileh S, Faramarzpour M, Zandi A, et al.. Capture-Free Deactivation of Ctcs in the Bloodstream; a Metastasis Suppression Method by Electrostatic Stimulation of the Peripheral Blood. Biosensors and Bioelectronics. 2021;183():-.
BibTex	@article{ author = {Ghaderinia M and Khayamian MA and Abadijoo H and Shalileh S and Faramarzpour M and Zandi A and Simaee H and Abbasvandi F and Esmailinejad MR and Rafizadehtafti S and Jahangiri M and Kordehlachin Y and Ghaffari H and Ansari E and Dabbagh N and Akbari ME and Hoseinpour P and Abdolahad M}, title = {Capture-Free Deactivation of Ctcs in the Bloodstream; a Metastasis Suppression Method by Electrostatic Stimulation of the Peripheral Blood}, journal = {Biosensors and Bioelectronics}, volume = {183}, number = {}, pages = {-}, year = {2021} }
RIS	TY - JOUR AU - Ghaderinia M AU - Khayamian MA AU - Abadijoo H AU - Shalileh S AU - Faramarzpour M AU - Zandi A AU - Simaee H AU - Abbasvandi F AU - Esmailinejad MR AU - Rafizadehtafti S AU - Jahangiri M AU - Kordehlachin Y AU - Ghaffari H AU - Ansari E AU - Dabbagh N AU - Akbari ME AU - Hoseinpour P AU - Abdolahad M TI - Capture-Free Deactivation of Ctcs in the Bloodstream; a Metastasis Suppression Method by Electrostatic Stimulation of the Peripheral Blood JO - Biosensors and Bioelectronics VL - 183 IS - SP - EP - PY - 2021 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract