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Validity and Reliability of the Persian Version of the Gastroesophageal Reflux Disease Health-Related Quality of Life Questionnaire Publisher



Ebrahimi SA1 ; Mostafavian Z2 ; Karazhian E3 ; Najafi F4 ; Mashoufi R1 ; Zandbaf T5 ; Mokhtari E6
Authors
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Authors Affiliations
  1. 1. Medical Sciences, Islamic Azad University, Mashhad, Iran
  2. 2. Department of Community Medicine, Islamic Azad University, Mashhad, Iran
  3. 3. Department of Medical-Surgical Nursing, Mashhad University of Medical Sciences, Mashhad, Iran
  4. 4. Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of General Surgery, Islamic Azad University, Mashhad, Iran
  6. 6. Department of Internal Medicine, Islamic Azad University, Mashhad, Iran

Source: BMJ Open Gastroenterology Published:2024


Abstract

Objective The Gastroesophageal Reflux Disease Health-Related Quality of Life (GERD-HRQL) is one of the most widely used questionnaires for assessing typical gastro-oesophageal reflux disease (GORD) symptoms. It is simple, concise, and treatment responsive, yet it has not been validated in the Persian language. This study aimed to translate the GERD-HRQL questionnaire into Persian and assess its validity and reliability. Design In this cross-sectional validation study, a team of gastroenterologists, general surgeons, and professional translators conducted the forward-backward translation. A gastroenterologist interviewed 10 patients with GORD to insure understandability of the questionnaire. Fifty-four patients with GORD and 60 patients with gastrointestinal complaints other than GORD were enrolled using convenience sampling method. To assess concurrent validity, patients with GORD completed the Persian GERD-HRQL and the WHO Quality of Life Brief Version (WHOQOL-BREF) questionnaires. To assess discriminant validity, GERD-HRQL scores were compared between GORD and non-GORD patients. After 2 weeks, the patients with GORD completed the GERD-HRQL questionnaire again to assess test–retest reliability. The internal consistency was measured using Cronbach’s alpha. Results The mean age of the GORD participants was 36.90±10.44, and the majority were women (78%). All GERD-HRQL domains and total scores exhibited significant negative correlations with WHOQOL-BREF domains (ranging from −0.28 to −0.97). The GERD-HRQL scores were significantly different in GORD and non-GORD patients (p<0.001). Test and retest scores did not show any significant differences (p=0.49). Cronbach’s alpha was 0.85. Conclusion The Persian GERD-HRQL questionnaire is valid and reliable and can effectively assess the GORD symptoms in Persian-speaking individuals. © Author(s) (or their employer(s)) 2024.