Tendency to Acidosis or Alkalosis: Which One Is Associated With Coronary Artery Disease? Publisher



Amirzadegan A ; Mohseni E ; Aghajani H ; Jalali A ; Vakilibasir A ; Yeganeh K
Source: Journal of Cardiovascular and Thoracic Research Published:2025

Abstract

Introduction: Base excess (BE) is an indicator of non-respiratory acid-base imbalances, which can impact coronary artery disease (CAD). This study evaluated the association between the severity of CAD and peripheral blood BE. Methods: This cross-sectional study included patients aged 18 and older who were candidates for coronary angiography. Demographic and clinical data were collected from medical records. Blood gas analysis was performed on a 2-millilitre arterial blood sample taken from the access artery before contrast injection. All patients underwent coronary angiography, and the Gensini score was calculated. Results: A total of 351 patients (194 males, 55.3%) were included in the study. The study population had a mean age of 60.79 ± 9.5 and a mean BMI of 29.4 ± 4.85. Coronary angiography revealed normal or minimal (< 50% stenosis) findings in 51.3% of cases (15.4% with normal coronary arteries and 35.9% with minimal non-obstructive lesions), single-vessel disease in 17.4%, two-vessel disease in 14.5%, and three-vessel disease in 16.8%. Median Gensini score was 13.0, with an IQR of 3.5 and 49. The findings indicated that a decrease in BE was significantly correlated with elevated Gensini scores (β:-0.04; 95% CI:-0.08 to-0.01; P = 0.027). However, BE did not significantly affect the Gensini score of 0 (P = 0.843). Moreover, negative values of BE were significantly and inversely associated with the Gensini score (β =-0.05; 95% CI:-0.07 to-0.02, P < 0.001). Conclusion: This study revealed an association between BE and CAD, suggesting that BE tending to acidosis is potentially associated with CAD. © 2025 The Author(s).