Selective Inducible Nitric Oxide Synthase Inhibitor Reversed Zinc Chloride-Induced Spatial Memory Impairment Via Increasing Cholinergic Marker Expression

Selective Inducible Nitric Oxide Synthase Inhibitor Reversed Zinc Chloride-Induced Spatial Memory Impairment Via Increasing Cholinergic Marker Expression Publisher Pubmed

Tabrizian K¹ ; Azami K² ; Belaran M³ ; Soodi M⁴ ; Abdi K⁵ ; Fanoudi S⁶ ; Sanati M⁷ ; Mottaghi Dastjerdi N⁷ ; Soltany Rezaeerad M⁷ ; Sharifzadeh M⁷

Show Affiliations

1. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran
2. Family Health Research Center, Iranian Petroleum Industry Health Research Institute, Tehran, Iran
3. Department of Physiology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
4. Department of Toxicology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
5. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
6. Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
7. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences, P.O. Box 14155-6451, Tehran, Iran

Source: Biological Trace Element Research Published:2016

Abstract

Zinc, an essential micronutrient and biochemical element of the human body, plays structural, catalytic, and regulatory roles in numerous physiological functions. In the current study, the effects of a pretraining oral administration of zinc chloride (10, 25, and 50 mg/kg) for 14 consecutive days and post-training bilateral intra-hippocampal infusion of 1400W as a selective inducible nitric oxide synthase (iNOS) inhibitor (10, 50, and 100 μM/side), alone and in combination, on the spatial memory retention in Morris water maze (MWM) were investigated. Animals were trained for 4 days and tested 48 h after completion of training. Also, the molecular effects of these compounds on the expression of choline acetyltransferase (ChAT), as a cholinergic marker in the CA1 region of the hippocampus and medial septal area (MSA), were evaluated. Behavioral and molecular findings of this study showed that a 2-week oral administration of zinc chloride (50 mg/kg) impaired spatial memory retention in MWM and decreased ChAT expression. Immunohistochemical analysis of post-training bilateral intra-hippocampal infusion of 1400W revealed a significant increase in ChAT immunoreactivity. Furthermore, post-training bilateral intra-hippocampal infusion of 1400W into the CA1 region of the hippocampus reversed zinc chloride-induced spatial memory impairment in MWM and significantly increased ChAT expression in comparison with zinc chloride-treated animals. Taken together, these results emphasize the role of selective iNOS inhibitors in reversing zinc chloride-induced spatial memory deficits via modulation of cholinergic marker expression. © 2016, Springer Science+Business Media New York.

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Style	Citing Format
MLA	Tabrizian K, et al.. "Selective Inducible Nitric Oxide Synthase Inhibitor Reversed Zinc Chloride-Induced Spatial Memory Impairment Via Increasing Cholinergic Marker Expression." Biological Trace Element Research, vol. 173, no. 2, 2016, pp. 443-451.
APA	Tabrizian K, Azami K, Belaran M, Soodi M, Abdi K, Fanoudi S, Sanati M, Mottaghi Dastjerdi N, Soltany Rezaeerad M, Sharifzadeh M (2016). Selective Inducible Nitric Oxide Synthase Inhibitor Reversed Zinc Chloride-Induced Spatial Memory Impairment Via Increasing Cholinergic Marker Expression. Biological Trace Element Research, 173(2), 443-451.
Chicago	Tabrizian K, Azami K, Belaran M, Soodi M, Abdi K, Fanoudi S, Sanati M, Mottaghi Dastjerdi N, Soltany Rezaeerad M, Sharifzadeh M. "Selective Inducible Nitric Oxide Synthase Inhibitor Reversed Zinc Chloride-Induced Spatial Memory Impairment Via Increasing Cholinergic Marker Expression." Biological Trace Element Research 173, no. 2 (2016): 443-451.
Harvard	Tabrizian K et al. (2016) 'Selective Inducible Nitric Oxide Synthase Inhibitor Reversed Zinc Chloride-Induced Spatial Memory Impairment Via Increasing Cholinergic Marker Expression', Biological Trace Element Research, 173(2), pp. 443-451.
Vancouver	Tabrizian K, Azami K, Belaran M, Soodi M, Abdi K, Fanoudi S, et al.. Selective Inducible Nitric Oxide Synthase Inhibitor Reversed Zinc Chloride-Induced Spatial Memory Impairment Via Increasing Cholinergic Marker Expression. Biological Trace Element Research. 2016;173(2):443-451.
BibTex	@article{ author = {Tabrizian K and Azami K and Belaran M and Soodi M and Abdi K and Fanoudi S and Sanati M and Mottaghi Dastjerdi N and Soltany Rezaeerad M and Sharifzadeh M}, title = {Selective Inducible Nitric Oxide Synthase Inhibitor Reversed Zinc Chloride-Induced Spatial Memory Impairment Via Increasing Cholinergic Marker Expression}, journal = {Biological Trace Element Research}, volume = {173}, number = {2}, pages = {443-451}, year = {2016} }
RIS	TY - JOUR AU - Tabrizian K AU - Azami K AU - Belaran M AU - Soodi M AU - Abdi K AU - Fanoudi S AU - Sanati M AU - Mottaghi Dastjerdi N AU - Soltany Rezaeerad M AU - Sharifzadeh M TI - Selective Inducible Nitric Oxide Synthase Inhibitor Reversed Zinc Chloride-Induced Spatial Memory Impairment Via Increasing Cholinergic Marker Expression JO - Biological Trace Element Research VL - 173 IS - 2 SP - 443 EP - 451 PY - 2016 ER -

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