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The Involvement of Medial Septum 5-Ht1 and 5-Ht2 Receptors on Acpa-Induced Memory Consolidation Deficit: Possible Role of Trpc3, Trpc6 and Trpv2 Publisher Pubmed



Najar F1 ; Nasehi M2 ; Haerirohani SA1 ; Zarrindast MR2, 3, 4, 5, 6
Authors
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Authors Affiliations
  1. 1. Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
  2. 2. Cognitive and Neuroscience Research Center (CNRC), Medical Genomics Research Center, School of Advanced Sciences in Medicine, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran
  3. 3. Department of Pharmacology School of Medicine, Tehran University of Basic Sciences, Tehran, Iran
  4. 4. Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. School of Cognitive Sciences, Institute for Research in Fundamental Sciences (IPM), Tehran, Iran
  6. 6. Substance Abuse and Dependence Research Center, University of School Welfare and Rehabilitation Sciences, Tehran, Iran

Source: Journal of Psychopharmacology Published:2015


Abstract

The present study evaluates the roles of serotonergic receptors of the medial septum on amnesia induced by arachidonylcyclopropylamide (ACPA; as selective cannabinoid CB1 receptor agonist) in adult male Wistar rats. Cannulae were implanted in the medial septum of the brain of the rats. The animals were trained in a passive avoidance learning apparatus, and were tested 24 hours after training for step-through latency. Results indicated that post-training medial septum administration of CP94253 (5-HT1B/1D receptor agonist) and cinancerine (as 5-HT2 receptor antagonist) reduced the step-through latency showing an amnesic response, while GR127935 (5-HT1B/1D receptor antagonist) and αm5htm (as 5-HT2A/2B/2D receptor agonist) did not alter memory consolidation by themselves. On continuing the test, the results showed that CP94253 increased and GR127935 did not alter ACPA (0.02 μg/rat)-induced memory impairment, respectively. Other data indicated that αm5htm induced a modulatory effect, while cinancerine restored ACPA-induced amnesia. Using SKF-96365 (inhibitor of transient receptor potential TRPC3/6 and TRPV2 channels) demonstrated that TRPC3, TRPC3 and TRPV2 channels have a significant role, according to our results. © British Association for Psychopharmacology.
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