Crystal Structures and in Vitro Anticancer Studies on New Unsymmetrical Copper(Ii) Schiff Base Complexes Derived From Meso-1,2-Diphenyl-1,2-Ethylenediamine: A Comparison With Related Symmetrical Ones

Crystal Structures and in Vitro Anticancer Studies on New Unsymmetrical Copper(Ii) Schiff Base Complexes Derived From Meso-1,2-Diphenyl-1,2-Ethylenediamine: A Comparison With Related Symmetrical Ones Publisher

Behzad M¹ ; Seifikar Ghomi L¹ ; Damercheli M¹ ; Mehravi B² ; Shafiee Ardestani M³ ; Samari Jahromi H⁴ ; Abbasi Z¹

Show Affiliations

1. Department of Chemistry, Semnan University, Semnan, Iran
2. Faculty of Advanced Technology in Medicine, Department of Medical Nanotechnology, Iran University of Medical Science, Tehran, Iran
3. Faculty of Pharmacy, Department of Radiopharmacy, Tehran University of Medical Sciences, Tehran, Iran
4. Environment and Biotechnology Division, Research Institute of Petroleum Industry (RIPI), Tehran, Iran

Source: Journal of Coordination Chemistry Published:2016

Abstract

Two new unsymmetrical copper(II) Schiff base complexes, [CuLn(py)]ClO4 (n = 1, 2) in which Ln represents a tridentate N2O type Schiff base ligand, were synthesized. Lns were derived from monocondensation of meso-1,2-diphenyl-1,2-ethylenediamine with salicylaldehyde or 3-methoxysalicylaldehyde. The reaction between [CuLn(py)]ClO4 and other salicylaldehyde derivatives resulted in new N2O2 unsymmetrical tetradentate CuII complexes, CuL3–6. Crystal structures of [CuL1(py)]ClO4, CuL4, and CuL5 were obtained. These new complexes as well as a series of related symmetrical ones (i.e. CuL7–12) were tested for their in vitro anticancer activity against human liver cancer cell line (Hep-G2) by MTT and apoptosis assay. All of the complexes showed considerable cytotoxic activity against tumor cell lines (IC50 = 5.13–16.24 μg mL−1). The symmetrical CuL7 was the most potent anticancer derivative (IC50 = 5.13 μg mL−1) compared to the control drug 5-FU (IC50 = 5.4 μg mL-1, p < 0.05). Flow cytometry experiments showed that the copper derivatives especially [CuL2(py)]ClO4 and CuL7 induced more apoptosis on Hep-G2 tumor cell lines compared to 5-FU. © 2016 Informa UK Limited, trading as Taylor & Francis Group.

Style	Citing Format
MLA	Behzad M, et al.. "Crystal Structures and in Vitro Anticancer Studies on New Unsymmetrical Copper(Ii) Schiff Base Complexes Derived From Meso-1,2-Diphenyl-1,2-Ethylenediamine: A Comparison With Related Symmetrical Ones." Journal of Coordination Chemistry, vol. 69, no. 16, 2016, pp. 2469-2481.
APA	Behzad M, Seifikar Ghomi L, Damercheli M, Mehravi B, Shafiee Ardestani M, Samari Jahromi H, Abbasi Z (2016). Crystal Structures and in Vitro Anticancer Studies on New Unsymmetrical Copper(Ii) Schiff Base Complexes Derived From Meso-1,2-Diphenyl-1,2-Ethylenediamine: A Comparison With Related Symmetrical Ones. Journal of Coordination Chemistry, 69(16), 2469-2481.
Chicago	Behzad M, Seifikar Ghomi L, Damercheli M, Mehravi B, Shafiee Ardestani M, Samari Jahromi H, Abbasi Z. "Crystal Structures and in Vitro Anticancer Studies on New Unsymmetrical Copper(Ii) Schiff Base Complexes Derived From Meso-1,2-Diphenyl-1,2-Ethylenediamine: A Comparison With Related Symmetrical Ones." Journal of Coordination Chemistry 69, no. 16 (2016): 2469-2481.
Harvard	Behzad M et al. (2016) 'Crystal Structures and in Vitro Anticancer Studies on New Unsymmetrical Copper(Ii) Schiff Base Complexes Derived From Meso-1,2-Diphenyl-1,2-Ethylenediamine: A Comparison With Related Symmetrical Ones', Journal of Coordination Chemistry, 69(16), pp. 2469-2481.
Vancouver	Behzad M, Seifikar Ghomi L, Damercheli M, Mehravi B, Shafiee Ardestani M, Samari Jahromi H, et al.. Crystal Structures and in Vitro Anticancer Studies on New Unsymmetrical Copper(Ii) Schiff Base Complexes Derived From Meso-1,2-Diphenyl-1,2-Ethylenediamine: A Comparison With Related Symmetrical Ones. Journal of Coordination Chemistry. 2016;69(16):2469-2481.
BibTex	@article{ author = {Behzad M and Seifikar Ghomi L and Damercheli M and Mehravi B and Shafiee Ardestani M and Samari Jahromi H and Abbasi Z}, title = {Crystal Structures and in Vitro Anticancer Studies on New Unsymmetrical Copper(Ii) Schiff Base Complexes Derived From Meso-1,2-Diphenyl-1,2-Ethylenediamine: A Comparison With Related Symmetrical Ones}, journal = {Journal of Coordination Chemistry}, volume = {69}, number = {16}, pages = {2469-2481}, year = {2016} }
RIS	TY - JOUR AU - Behzad M AU - Seifikar Ghomi L AU - Damercheli M AU - Mehravi B AU - Shafiee Ardestani M AU - Samari Jahromi H AU - Abbasi Z TI - Crystal Structures and in Vitro Anticancer Studies on New Unsymmetrical Copper(Ii) Schiff Base Complexes Derived From Meso-1,2-Diphenyl-1,2-Ethylenediamine: A Comparison With Related Symmetrical Ones JO - Journal of Coordination Chemistry VL - 69 IS - 16 SP - 2469 EP - 2481 PY - 2016 ER -

Style

Citing Format

MLA

Behzad M, et al.. "Crystal Structures and in Vitro Anticancer Studies on New Unsymmetrical Copper(Ii) Schiff Base Complexes Derived From Meso-1,2-Diphenyl-1,2-Ethylenediamine: A Comparison With Related Symmetrical Ones." Journal of Coordination Chemistry, vol. 69, no. 16, 2016, pp. 2469-2481.

APA

Behzad M, Seifikar Ghomi L, Damercheli M, Mehravi B, Shafiee Ardestani M, Samari Jahromi H, Abbasi Z (2016). Crystal Structures and in Vitro Anticancer Studies on New Unsymmetrical Copper(Ii) Schiff Base Complexes Derived From Meso-1,2-Diphenyl-1,2-Ethylenediamine: A Comparison With Related Symmetrical Ones. Journal of Coordination Chemistry, 69(16), 2469-2481.

Chicago

Behzad M, Seifikar Ghomi L, Damercheli M, Mehravi B, Shafiee Ardestani M, Samari Jahromi H, Abbasi Z. "Crystal Structures and in Vitro Anticancer Studies on New Unsymmetrical Copper(Ii) Schiff Base Complexes Derived From Meso-1,2-Diphenyl-1,2-Ethylenediamine: A Comparison With Related Symmetrical Ones." Journal of Coordination Chemistry 69, no. 16 (2016): 2469-2481.

Harvard

Behzad M et al. (2016) 'Crystal Structures and in Vitro Anticancer Studies on New Unsymmetrical Copper(Ii) Schiff Base Complexes Derived From Meso-1,2-Diphenyl-1,2-Ethylenediamine: A Comparison With Related Symmetrical Ones', Journal of Coordination Chemistry, 69(16), pp. 2469-2481.

Vancouver

Behzad M, Seifikar Ghomi L, Damercheli M, Mehravi B, Shafiee Ardestani M, Samari Jahromi H, et al.. Crystal Structures and in Vitro Anticancer Studies on New Unsymmetrical Copper(Ii) Schiff Base Complexes Derived From Meso-1,2-Diphenyl-1,2-Ethylenediamine: A Comparison With Related Symmetrical Ones. Journal of Coordination Chemistry. 2016;69(16):2469-2481.

BibTex

@article{ author = {Behzad M and Seifikar Ghomi L and Damercheli M and Mehravi B and Shafiee Ardestani M and Samari Jahromi H and Abbasi Z}, title = {Crystal Structures and in Vitro Anticancer Studies on New Unsymmetrical Copper(Ii) Schiff Base Complexes Derived From Meso-1,2-Diphenyl-1,2-Ethylenediamine: A Comparison With Related Symmetrical Ones}, journal = {Journal of Coordination Chemistry}, volume = {69}, number = {16}, pages = {2469-2481}, year = {2016} }

RIS

TY - JOUR
AU - Behzad M
AU - Seifikar Ghomi L
AU - Damercheli M
AU - Mehravi B
AU - Shafiee Ardestani M
AU - Samari Jahromi H
AU - Abbasi Z
TI - Crystal Structures and in Vitro Anticancer Studies on New Unsymmetrical Copper(Ii) Schiff Base Complexes Derived From Meso-1,2-Diphenyl-1,2-Ethylenediamine: A Comparison With Related Symmetrical Ones
JO - Journal of Coordination Chemistry
VL - 69
IS - 16
SP - 2469
EP - 2481
PY - 2016
ER -

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