New Salen-Type Manganese(Iii) Schiff Base Complexes Derived From Meso -1,2-Diphenyl-1,2-Ethylenediamine: In Vitro Anticancer Activity, Mechanism of Action, and Molecular Docking Studies

New Salen-Type Manganese(Iii) Schiff Base Complexes Derived From Meso -1,2-Diphenyl-1,2-Ethylenediamine: In Vitro Anticancer Activity, Mechanism of Action, and Molecular Docking Studies Publisher

Damercheli M¹ ; Dayyani D¹ ; Behzad M¹ ; Mehravi B² ; Shafiee Ardestani M³

Show Affiliations

1. Departmentof Chemistry, Semnan University, Semnan, Iran
2. Faculty of Advanced Technology in Medicine, Department of Medical Nanotechnology, Iran University of Medical Sciences, Tehran, Iran
3. Faculty of Pharmacy, Department of Radiopharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Coordination Chemistry Published:2015

Abstract

Four new manganese(III) Schiff base complexes (1-4) were synthesized and characterized. The complexes have general formula [MnClLx] in which L represents a Schiff base ligand derived from condensation of meso-1,2-diphenyl-1,2-ethylenediamine with salicylaldehyde or its 3-OMe-, 5-Br-, or 5-OMe-derivatives (x = 1-4, respectively). The crystal structure of [MnClL1] (1) was characterized by X-ray crystallography. The in vitro anticancer activity of these complexes was evaluated by MTT and apoptosis assays against human breast (MCF-7) and liver (Hep G2) cancer cells. The complexes exhibited considerable antiproliferative activity against both cell lines (IC50 = 10.8-21.02 M) comparable to cis-platin, except 4 (MCF-7). The highest activity was found for 1 with IC50 values of 13.62 M (MCF-7) and 10.8 M (Hep G2). Flow cytometry experiments showed that 1 induced apoptosis on MCF-7 tumor cell line. Docking simulations using AUTODOCK were also carried out. The results showed that all complexes fitted into the minor groove region of DNA. © 2015 Taylor & Francis.

Style	Citing Format
MLA	Damercheli M, et al.. "New Salen-Type Manganese(Iii) Schiff Base Complexes Derived From Meso -1,2-Diphenyl-1,2-Ethylenediamine: In Vitro Anticancer Activity, Mechanism of Action, and Molecular Docking Studies." Journal of Coordination Chemistry, vol. 68, no. 9, 2015, pp. 1500-1513.
APA	Damercheli M, Dayyani D, Behzad M, Mehravi B, Shafiee Ardestani M (2015). New Salen-Type Manganese(Iii) Schiff Base Complexes Derived From Meso -1,2-Diphenyl-1,2-Ethylenediamine: In Vitro Anticancer Activity, Mechanism of Action, and Molecular Docking Studies. Journal of Coordination Chemistry, 68(9), 1500-1513.
Chicago	Damercheli M, Dayyani D, Behzad M, Mehravi B, Shafiee Ardestani M. "New Salen-Type Manganese(Iii) Schiff Base Complexes Derived From Meso -1,2-Diphenyl-1,2-Ethylenediamine: In Vitro Anticancer Activity, Mechanism of Action, and Molecular Docking Studies." Journal of Coordination Chemistry 68, no. 9 (2015): 1500-1513.
Harvard	Damercheli M et al. (2015) 'New Salen-Type Manganese(Iii) Schiff Base Complexes Derived From Meso -1,2-Diphenyl-1,2-Ethylenediamine: In Vitro Anticancer Activity, Mechanism of Action, and Molecular Docking Studies', Journal of Coordination Chemistry, 68(9), pp. 1500-1513.
Vancouver	Damercheli M, Dayyani D, Behzad M, Mehravi B, Shafiee Ardestani M. New Salen-Type Manganese(Iii) Schiff Base Complexes Derived From Meso -1,2-Diphenyl-1,2-Ethylenediamine: In Vitro Anticancer Activity, Mechanism of Action, and Molecular Docking Studies. Journal of Coordination Chemistry. 2015;68(9):1500-1513.
BibTex	@article{ author = {Damercheli M and Dayyani D and Behzad M and Mehravi B and Shafiee Ardestani M}, title = {New Salen-Type Manganese(Iii) Schiff Base Complexes Derived From Meso -1,2-Diphenyl-1,2-Ethylenediamine: In Vitro Anticancer Activity, Mechanism of Action, and Molecular Docking Studies}, journal = {Journal of Coordination Chemistry}, volume = {68}, number = {9}, pages = {1500-1513}, year = {2015} }
RIS	TY - JOUR AU - Damercheli M AU - Dayyani D AU - Behzad M AU - Mehravi B AU - Shafiee Ardestani M TI - New Salen-Type Manganese(Iii) Schiff Base Complexes Derived From Meso -1,2-Diphenyl-1,2-Ethylenediamine: In Vitro Anticancer Activity, Mechanism of Action, and Molecular Docking Studies JO - Journal of Coordination Chemistry VL - 68 IS - 9 SP - 1500 EP - 1513 PY - 2015 ER -

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