Autophagy Induced by Helicobacter Pylori Infection Can Lead to Gastric Cancer Dormancy, Metastasis, and Recurrence: New Insights Publisher Pubmed



Akbari A^{1, 2} ; Noorbakhsh Varnosfaderani SM³ ; Haeri MS⁴ ; Fathi Z⁵ ; Aziziyan F^{2, 6} ; Yousefi Rad A⁷ ; Zalpoor H^{1, 2} ; Nabiafjadi M⁶ ; Malekzadegan Y⁸ Show Affiliations
Source: Human Cell Published:2024

Abstract

According to the findings of recent research, Helicobacter Pylori (H. pylori) infection is not only the primary cause of gastric cancer (GC), but it is also linked to the spread and invasion of GC through a number of processes and factors that contribute to virulence. In this study, we discussed that H. pylori infection can increase autophagy in GC tumor cells, leading to poor prognosis in such patients. Until now, the main concerns have been focused on H. pylori’s role in GC development. According to our hypothesis, however, H. pylori infection may also lead to GC dormancy, metastasis, and recurrence by stimulating autophagy. Therefore, understanding how H. pylori possess these processes through its virulence factors and various microRNAs can open new windows for providing new prevention and/or therapeutic approaches to combat GC dormancy, metastasis, and recurrence which can occur in GC patients with H. pylori infection with targeting autophagy and eradicating H. pylori infection. © 2023, The Author(s) under exclusive licence to Japan Human Cell Society.