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The Question of Survival or Death: What Is the Role of Autophagy in Acute Myeloid Leukemia (Aml)? Publisher



Haghi A1, 2, 3 ; Kian MM3, 4 ; Salemi M1, 3 ; Eghdami MR5, 6 ; Nikbakht M1, 3
Authors
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Authors Affiliations
  1. 1. Research Institute for Oncology, Hematology and Cell Therapy, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Young Researchers and Elite Club, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  3. 3. Cell Therapy and Hematopoietic Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Social Sciences, University of Guilan, Rasht, Iran
  6. 6. Department of Biological Anthropology, Research Institute of Guilan Studies, University of Guilan, Rasht, Iran

Source: International Journal of Hematology-Oncology and Stem Cell Research Published:2022


Abstract

Autophagy plays a critical role in balancing sources of energy in response to harsh conditions and nutrient deprivation. Autophagy allows cells to survive in harsh condition and also serve as a death mechanism. Any dysregulation in autophagy signaling may lead to several disorders. Autophagy has been proposed to explain chemotherapy resistance in acute myeloid leukemia (AML). This signaling pathway can either act as a tumor suppressive function or chemo-resistance mechanism. Conventional chemotherapy drugs enhance apoptosis and indicate clinical benefit, but in some cases, relapse and chemotherapy resistance are observed. In leukemia, autophagy may promote cell survival in response to chemotherapy drugs. Therefore, new strategies by inhibiting or activating autophagy may find a broad application for treating leukemia and may significantly enhance clinical outcomes. In this review, we discussed how dimensional role of autophagy in leukemia. © 2022 Tehran University of Medical Sciences.
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