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Enhanced Beta-Catenin Expression Is Associated With Recurrence of Papillary Thyroid Carcinoma Publisher Pubmed



Kordestani Z1, 5 ; Sanjari M2 ; Safavi M3 ; Mashrouteh M4 ; Asadikaram G2 ; Abadi MFS5 ; Mirzazadeh A6
Authors
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Authors Affiliations
  1. 1. Medical Biotechnology Research Center, Ashkezar Branch, Islamic Azad University, Ashkezar, Yazd, Iran
  2. 2. Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran
  3. 3. Pathology Department, Medical Faculty, Tehran University of Medical Science, Tehran, Iran
  4. 4. Modeling in Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran
  5. 5. Physiology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran
  6. 6. Global Health Science, University of California, San Francisco, CA, United States

Source: Endocrine Practice Published:2018


Abstract

Objective: A direct role of β-catenin 1 (β-cat) in the proliferation of human thyroid tumor cells has been identified. This study aimed to determine if there is an association between β-cat gene expression and the staging, recurrence, metastasis, and disease-free survival of papillary thyroid cancer. Methods: A retrospective cohort study was conducted using data from available information in the medical records and paraffin blocks of 81 of 400 patients referred to the endocrine clinic over a 10-year period. Real-time polymerase chain reaction was used to evaluate β-cat gene expression. Disease-free survival was assessed using the Kaplan-Meier method. Results: The 10-year survival rate in these patients was 98.25%, and disease-free survival was 48.1%. Cumulative dose of radioactive iodine that patients received was significantly and positively correlated with β-cat gene expression (r = −0.2; P = .03). Also, in patients with recurrence, β-cat gene expression was higher and statistically significant (5-fold increase; P = .002). Patients in more advanced stage and those with recurrence/distant metastasis had higher β-cat gene expression. We found that the patients had a better survival (lower recurrence) if they had a lower β-cat gene expression (SD, 0.142 to 0.052) (Mantel-Cox test, P = .002). Conclusion: We conclude that β-cat gene expression is positively correlated with recurrence, distant metastasis, and tumor-node-metastasis stage. Copyright © 2018 AACE.