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The Role of Micrornas in Different Types of Thyroid Carcinoma: A Comprehensive Analysis to Find New Mirna Supplementary Therapies Publisher Pubmed



Pishkari S1 ; Paryan M2 ; Hashemi M1 ; Baldini E3 ; Mohammadiyeganeh S4, 5
Authors
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Authors Affiliations
  1. 1. Department of Medicine, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran
  2. 2. Department of Research and Development, Production and Research Complex, Pasteur Institute of Iran, Tehran, Iran
  3. 3. Department of Surgical Sciences, University of Rome, Rome, Italy
  4. 4. Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Journal of Endocrinological Investigation Published:2018


Abstract

The most common endocrine malignancy is thyroid cancer, and researchers have made a great deal of progress in deciphering its molecular mechanisms in the recent years. Many of molecular changes observed in thyroid cancer can be used as biomarkers for diagnosis, prognosis, and therapeutic targets for treatment. MicroRNAs (miRNAs) are important parts in biological and metabolic pathways such as regulation of developmental stages, signal transduction, cell maintenance, and differentiation. Therefore, their dysregulation can expose individuals to malignancies. It has been proved that miRNA expression is dysregulated in different types of tumors, like thyroid cancers, and can be the cause of tumor initiation and progression. In this paper, we have reviewed the available data on miRNA dysregulation in different thyroid tumors including papillary, follicular, anaplastic, and medullary thyroid carcinomas aiming to introduce the last updates in miRNAs-thyroid cancer relation. © 2017, Italian Society of Endocrinology (SIE).
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