Conjugated Anionic Peg-Citrate G2 Dendrimer With Multi-Epitopic Hiv-1 Vaccine Candidate Enhance the Cellular Immune Responses in Mice

Conjugated Anionic Peg-Citrate G2 Dendrimer With Multi-Epitopic Hiv-1 Vaccine Candidate Enhance the Cellular Immune Responses in Mice Publisher Pubmed

Abdoli A¹ ; Radmehr N² ; Bolhassani A¹ ; Eidi A² ; Mehrbod P³ ; Motevalli F¹ ; Kianmehr Z⁴ ; Chiani M⁵ ; Mahdavi M⁶ ; Yazdani S⁷ ; Ardestani MS⁸ ; Kandi MR⁹ ; Aghasadeghi MR¹

Show Affiliations

1. Hepatitis and AIDS Department, Pasteur Institute of Iran, Tehran, Iran
2. Faculty of Basic Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran
3. Influenza and Other Respiratory Viruses Department, Pasteur Institute of Iran, Tehran, Iran
4. Immunoregulation Research Centre, Shahed University, Tehran, Iran
5. Department of Pilot Biotechnology, Pasteur Institute of Iran, Tehran, Iran
6. Department of Immunology, Pasteur Institute of Iran, Tehran, Iran
7. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
8. Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
9. Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Iran

Source: Artificial Cells# Nanomedicine and Biotechnology Published:2017

Abstract

Multi-epitope vaccines might cause immunity against multiple antigenic targets. Four immunodominant epitopes of HIV-1 genome were used to construct a polytope vaccine, formulated by dendrimer. Two regimens of polytopes mixture with dendrimer were utilized to immunize BALB/c mice. Adjuvants were also used to boost immune responses. The conjugated polytope could arouse significant cellular immune responses (P < 0.05) and Th1 response showed higher intensity compared to Th2 (P < 0.05). Our study depicted that conjugated dendrimer with multi-epitopic rHIVtop4 would efficiently induce cell-mediated immune responses and might be considered as promising delivery system for vaccines formulation. © 2017 Informa UK Limited, trading as Taylor & Francis Group.

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Style	Citing Format
MLA	Abdoli A, et al.. "Conjugated Anionic Peg-Citrate G2 Dendrimer With Multi-Epitopic Hiv-1 Vaccine Candidate Enhance the Cellular Immune Responses in Mice." Artificial Cells# Nanomedicine and Biotechnology, vol. 45, no. 8, 2017, pp. 1762-1768.
APA	Abdoli A, Radmehr N, Bolhassani A, Eidi A, Mehrbod P, Motevalli F, Kianmehr Z, Chiani M, Mahdavi M, Yazdani S, Ardestani MS, Kandi MR, Aghasadeghi MR (2017). Conjugated Anionic Peg-Citrate G2 Dendrimer With Multi-Epitopic Hiv-1 Vaccine Candidate Enhance the Cellular Immune Responses in Mice. Artificial Cells# Nanomedicine and Biotechnology, 45(8), 1762-1768.
Chicago	Abdoli A, Radmehr N, Bolhassani A, Eidi A, Mehrbod P, Motevalli F, Kianmehr Z, et al.. "Conjugated Anionic Peg-Citrate G2 Dendrimer With Multi-Epitopic Hiv-1 Vaccine Candidate Enhance the Cellular Immune Responses in Mice." Artificial Cells# Nanomedicine and Biotechnology 45, no. 8 (2017): 1762-1768.
Harvard	Abdoli A et al. (2017) 'Conjugated Anionic Peg-Citrate G2 Dendrimer With Multi-Epitopic Hiv-1 Vaccine Candidate Enhance the Cellular Immune Responses in Mice', Artificial Cells# Nanomedicine and Biotechnology, 45(8), pp. 1762-1768.
Vancouver	Abdoli A, Radmehr N, Bolhassani A, Eidi A, Mehrbod P, Motevalli F, et al.. Conjugated Anionic Peg-Citrate G2 Dendrimer With Multi-Epitopic Hiv-1 Vaccine Candidate Enhance the Cellular Immune Responses in Mice. Artificial Cells# Nanomedicine and Biotechnology. 2017;45(8):1762-1768.
BibTex	@article{ author = {Abdoli A and Radmehr N and Bolhassani A and Eidi A and Mehrbod P and Motevalli F and Kianmehr Z and Chiani M and Mahdavi M and Yazdani S and Ardestani MS and Kandi MR and Aghasadeghi MR}, title = {Conjugated Anionic Peg-Citrate G2 Dendrimer With Multi-Epitopic Hiv-1 Vaccine Candidate Enhance the Cellular Immune Responses in Mice}, journal = {Artificial Cells# Nanomedicine and Biotechnology}, volume = {45}, number = {8}, pages = {1762-1768}, year = {2017} }
RIS	TY - JOUR AU - Abdoli A AU - Radmehr N AU - Bolhassani A AU - Eidi A AU - Mehrbod P AU - Motevalli F AU - Kianmehr Z AU - Chiani M AU - Mahdavi M AU - Yazdani S AU - Ardestani MS AU - Kandi MR AU - Aghasadeghi MR TI - Conjugated Anionic Peg-Citrate G2 Dendrimer With Multi-Epitopic Hiv-1 Vaccine Candidate Enhance the Cellular Immune Responses in Mice JO - Artificial Cells# Nanomedicine and Biotechnology VL - 45 IS - 8 SP - 1762 EP - 1768 PY - 2017 ER -

Style

Citing Format

MLA

Abdoli A, et al.. "Conjugated Anionic Peg-Citrate G2 Dendrimer With Multi-Epitopic Hiv-1 Vaccine Candidate Enhance the Cellular Immune Responses in Mice." Artificial Cells# Nanomedicine and Biotechnology, vol. 45, no. 8, 2017, pp. 1762-1768.

APA

Abdoli A, Radmehr N, Bolhassani A, Eidi A, Mehrbod P, Motevalli F, Kianmehr Z, Chiani M, Mahdavi M, Yazdani S, Ardestani MS, Kandi MR, Aghasadeghi MR (2017). Conjugated Anionic Peg-Citrate G2 Dendrimer With Multi-Epitopic Hiv-1 Vaccine Candidate Enhance the Cellular Immune Responses in Mice. Artificial Cells# Nanomedicine and Biotechnology, 45(8), 1762-1768.

Chicago

Abdoli A, Radmehr N, Bolhassani A, Eidi A, Mehrbod P, Motevalli F, Kianmehr Z, et al.. "Conjugated Anionic Peg-Citrate G2 Dendrimer With Multi-Epitopic Hiv-1 Vaccine Candidate Enhance the Cellular Immune Responses in Mice." Artificial Cells# Nanomedicine and Biotechnology 45, no. 8 (2017): 1762-1768.

Harvard

Abdoli A et al. (2017) 'Conjugated Anionic Peg-Citrate G2 Dendrimer With Multi-Epitopic Hiv-1 Vaccine Candidate Enhance the Cellular Immune Responses in Mice', Artificial Cells# Nanomedicine and Biotechnology, 45(8), pp. 1762-1768.

Vancouver

Abdoli A, Radmehr N, Bolhassani A, Eidi A, Mehrbod P, Motevalli F, et al.. Conjugated Anionic Peg-Citrate G2 Dendrimer With Multi-Epitopic Hiv-1 Vaccine Candidate Enhance the Cellular Immune Responses in Mice. Artificial Cells# Nanomedicine and Biotechnology. 2017;45(8):1762-1768.

BibTex

@article{ author = {Abdoli A and Radmehr N and Bolhassani A and Eidi A and Mehrbod P and Motevalli F and Kianmehr Z and Chiani M and Mahdavi M and Yazdani S and Ardestani MS and Kandi MR and Aghasadeghi MR}, title = {Conjugated Anionic Peg-Citrate G2 Dendrimer With Multi-Epitopic Hiv-1 Vaccine Candidate Enhance the Cellular Immune Responses in Mice}, journal = {Artificial Cells# Nanomedicine and Biotechnology}, volume = {45}, number = {8}, pages = {1762-1768}, year = {2017} }

RIS

TY - JOUR
AU - Abdoli A
AU - Radmehr N
AU - Bolhassani A
AU - Eidi A
AU - Mehrbod P
AU - Motevalli F
AU - Kianmehr Z
AU - Chiani M
AU - Mahdavi M
AU - Yazdani S
AU - Ardestani MS
AU - Kandi MR
AU - Aghasadeghi MR
TI - Conjugated Anionic Peg-Citrate G2 Dendrimer With Multi-Epitopic Hiv-1 Vaccine Candidate Enhance the Cellular Immune Responses in Mice
JO - Artificial Cells# Nanomedicine and Biotechnology
VL - 45
IS - 8
SP - 1762
EP - 1768
PY - 2017
ER -

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Abstract