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The Modulatory Potential of Herbal Antioxidants Against Oxidative Stress and Heavy Metal Pollution: Plants Against Environmental Oxidative Stress Publisher Pubmed



Omidifar N1 ; Niliahmadabadi A2 ; Nakhostinansari A3 ; Lankarani KB4 ; Moghadami M4 ; Mousavi SM5 ; Hashemi SA6 ; Gholami A7 ; Shokripour M8 ; Ebrahimi Z9
Authors
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Authors Affiliations
  1. 1. Clinical Education Research Center, and Department of Pathology, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran
  2. 2. Department of Pharmacology and Toxicology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran
  3. 3. Sports Medicine Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Health Policy Research Center, Health Institute, Shiraz University of Medical Sciences, Shiraz, Iran
  5. 5. Department of Chemical Engineering, National Taiwan University of Science and Technology, Taipei City, Taiwan
  6. 6. Nanomaterials and Polymer Nanocomposites Laboratory, School of Engineering, University of British Columbia, Kelowna, V1V 1V7, BC, Canada
  7. 7. Biotechnology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  8. 8. Depatment of Pathology, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran
  9. 9. Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran

Source: Environmental Science and Pollution Research Published:2021


Abstract

Free radicals, principally reactive oxygen species (ROS), contribute to oxidative stress in human beings. Free radicals have different mechanisms of action and affect lipids, proteins, and DNA. Heavy metals including cadmium (Cd), lead (Pb), and arsenic are environmental pollutants that may induce oxidative stress and produce ROS, leading to harmful effects on different body systems such as the liver and brain. On the other side, antioxidants can have protective effects against oxidative stress and decrease their toxicity. Herbal antioxidants have potential antioxidative effects. These antioxidants positively affect neurodegenerative diseases, atherosclerotic diseases, lung fibrosis, kidney injuries, and liver toxicities induced by oxidative agents, including heavy metals. In this manuscript, we explained the mechanisms of oxidative stress, and also discussed heavy metals which contribute to human oxidative stress. We further discussed different herbal antioxidants, their mechanisms of action, and their clinical use for various diseases. © 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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