Superoxide Dismutase: A Key Target for the Neuroprotective Effects of Curcumin Publisher Pubmed



Khayatan D^{1, 2} ; Razavi SM^{1, 2} ; Arab ZN^{1, 2} ; Hosseini Y^{1, 2} ; Niknejad A^{1, 2} ; Momtaz S^{2, 3, 4} ; Abdolghaffari AH^{1, 2, 3, 4} ; Sathyapalan T⁵ ; Jamialahmadi T^{6, 7} ; Kesharwani P^{8, 9} ; Sahebkar A^{6, 10, 11} Show Affiliations
Source: Molecular and Cellular Biochemistry Published:2024

Abstract

Over the past few years, the prevalence of neurodegenerative diseases (NDD) has increased dramatically. The community health system is burdened by the high healthcare costs associated with NDD. Superoxide dismutase (SOD) is a type of metalloenzyme that possesses a distinct characteristic of protecting the body from oxidative stress through antioxidants. In this way, SOD supplementation may activate the endogenous antioxidant mechanism in various pathological conditions and could be used to neutralize free radical excess. Several factors are responsible for damaging DNA and RNA in the body, including the overproduction of reactive species, particularly reactive oxygen species (ROS) and reactive nitrogen species (RNS). Excessive ROS/RNS have deleterious effects on mitochondria and their metabolic processes, mainly through increased mitochondrial proteins, lipids and DNA oxidation. Studies have shown that oxidative stress is implicated in the etiology of many diseases, including NDD. It is thought that anti-inflammatory compounds, particularly phytochemicals, can interfere with these pathways and regulate inflammation. Extensive experimental and clinical research has proven that curcumin (Cur) has anti-inflammatory and anti-neurologic properties. In this review, we have compiled the available data on Cur’s anti-inflammatory properties, paying special attention to its therapeutic impact on NDD through SOD. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023.