Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Systematic Review and Meta-Analysis of Association Between Plasminogen Activator Inhibitor-1 4G/5G Polymorphism and Recurrent Pregnancy Loss: An Update Publisher



Maghsudlu M1 ; Noroozi Z2 ; Zokaei E3 ; Motevaseli E2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Medical Genetics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Biology, Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman, Iran

Source: Thrombosis Journal Published:2024


Abstract

Background: We conducted this systematic review and meta-analysis to better understand the association between rs1799762 PAI-1 gene polymorphism and the risk of RPL. Methods: A systematic search for studies that assessed the association between PAI-1 4G/5G polymorphism and RPL risk published in search sources, PubMed/Medline, ISI Web of Knowledge, Scopus, and Google Scholar till January 2024 was conducted. Results: There were 23 case-control studies in total, with a high degree of statistical heterogeneity among them which indicated the need for subgroup analysis. We found a significant positive association between the risk of RPL and 4G/4G PAI-1 (OR: 2.57; 95% CI: 1.69-3.90), likewise 4G/5G (OR: 2/02 95% CI: 1.39-2.92) and mixed genotype (4G/4G+4G/5G) (OR: 2.31 95% CI: 1.81-2.93). Considering the ethnicity, the 4G/4G polymorphism is significantly associated with Asian descent (OR: 2.10; CI: 1.65-2.69) while the strong association (OR: 6.47; CI: 3.23-12.97) observed in the Greater Middle East descent is not statistically significant (P=0.16). PAI-1 4G/5G polymorphism association with RPL was only significant in Greater Middle East descent (OR: 2.93; CI: 2.41-3.56), and mixed genotype was significantly associated with RPL in Asian (OR: 2.37; CI: 1.55-3.61), Greater Middle East (OR: 3.01; CI: 2.16-4.19), and European populations (OR: 1.38; CI: 0.91-2.10). The association between RPL and PAI-1 4G/4G was significant for RPLs both under 12 weeks (OR: 1.82; 95% CI: 1.34-2.47), and under 24 weeks (OR: 1.46; 95% CI: 1.11-1.92), while considering heterozygote form the association was only significant for RPLs under 24 weeks (OR: 1.91; 95% CI: 1.58-2.31). Regarding the mixed genotype, there is a significant positive association between PAI-1 and RPL for RPLs under 12 weeks (OR: 2.09; 95% CI: 1.49-2.93), and under 24 weeks (OR: 2.10; 95% CI: 1.52-2.92). Conclusions: Our findings indicate a significant association between the rs1799762 PAI-1 polymorphism and the risk of RPL. © The Author(s) 2024.
Related Docs
1. Association Between Thrombophilic Genes Polymorphisms and Recurrent Pregnancy Loss Susceptibility in the Iranian Population: A Systematic Review and Meta-Analysis, Iranian Biomedical Journal (2018)
2. Association Between Thrombophilia Gene Polymorphisms and Recurrent Pregnancy Loss Risk in the Iranian Population, Systems Biology in Reproductive Medicine (2018)
3. Factor Vii R353q (Rs6046), Fga A6534g (Rs6050), and Fgg C10034t (Rs2066865) Gene Polymorphisms and Risk of Recurrent Pregnancy Loss in Iranian Women, Indian Journal of Hematology and Blood Transfusion (2024)
4. Methylenetetrahydrofolate Reductase C677t and A1298c Polymorphisms in Male Partners of Recurrent Miscarriage Couples, Journal of Reproduction and Infertility (2015)
5. Factor Xiii Val34leu Polymorphism and Risk of Recurrent Pregnancy Loss in Iranian Population: A Case Control Study, Frontiers in Biology (2016)
Experts (# of related papers)
View all Related Experts
Saeed Mohammadi (1)
Shaban Alizadeh (1)