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Factor Xiii Val34leu Polymorphism and Risk of Recurrent Pregnancy Loss in Iranian Population: A Case Control Study Publisher



Sajjadi SM1 ; Khosravi A2 ; Pakravesh J3 ; Soheili ZS4 ; Samiei S5 ; Mohammadi S6 ; Jalali Far MA5, 7
Authors

Source: Frontiers in Biology Published:2016


Abstract

BACKGROUND: Recurrent pregnancy loss (RPL) is a heterogeneous condition and thrombophilias have been considered as a probable cause. OBJECTIVE: The aim of this study was to investigate the prevalence of the coagulation factor XIII Val34Leu polymorphism among women with unexplained RPL. METHODS: A total of 140 women with a history of unexplained RPL and 100 age-matched healthy fertile women were recruited. The presence of FXIII Val34Leu polymorphism among the cases and controls was investigated using PCR-RFLP method. RESULTS: Genotype analyses of the subjects revealed that the patients had a significantly higher prevalence of V/L and L/L than the controls (P<0.05): 33.5% vs. 15%, and 9.2% vs. 2%, respectively. CONCLUSION: These results indicate a significant association between FXIII Val34Leu polymorphism and unexplained RPL in the Iranian patient. © 2016, Higher Education Press and Springer-Verlag Berlin Heidelberg.
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