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Factor Xiii Val34leu Polymorphism and Risk of Recurrent Pregnancy Loss in Iranian Population: A Case Control Study Publisher



Sajjadi SM1 ; Khosravi A2 ; Pakravesh J3 ; Soheili ZS4 ; Samiei S5 ; Mohammadi S6 ; Jalali Far MA5, 7
Authors
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Authors Affiliations
  1. 1. Cellular and Molecular Research Center of Birjand University of Medical Sciences, Biriand, Iran
  2. 2. Department of Hematology, Tehran University of Allied Medical Sciences, Tehran, Iran
  3. 3. Department of Obstetrics and Gynecology, Aban General Hospital, Tehran, Iran
  4. 4. Cellular and Molecular Biology, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran
  5. 5. Blood Transfusion Research center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
  6. 6. Hematology Oncology and Stem Cell Translantation Research Center, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Health research institute, Research Center of Thalassemia & Hemoglobinopathy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Source: Frontiers in Biology Published:2016


Abstract

BACKGROUND: Recurrent pregnancy loss (RPL) is a heterogeneous condition and thrombophilias have been considered as a probable cause. OBJECTIVE: The aim of this study was to investigate the prevalence of the coagulation factor XIII Val34Leu polymorphism among women with unexplained RPL. METHODS: A total of 140 women with a history of unexplained RPL and 100 age-matched healthy fertile women were recruited. The presence of FXIII Val34Leu polymorphism among the cases and controls was investigated using PCR-RFLP method. RESULTS: Genotype analyses of the subjects revealed that the patients had a significantly higher prevalence of V/L and L/L than the controls (P<0.05): 33.5% vs. 15%, and 9.2% vs. 2%, respectively. CONCLUSION: These results indicate a significant association between FXIII Val34Leu polymorphism and unexplained RPL in the Iranian patient. © 2016, Higher Education Press and Springer-Verlag Berlin Heidelberg.
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1. Association Between Thrombophilia Gene Polymorphisms and Recurrent Pregnancy Loss Risk in the Iranian Population, Systems Biology in Reproductive Medicine (2018)
2. Association Between Thrombophilic Genes Polymorphisms and Recurrent Pregnancy Loss Susceptibility in the Iranian Population: A Systematic Review and Meta-Analysis, Iranian Biomedical Journal (2018)
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