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Association Between Thrombophilic Genes Polymorphisms and Recurrent Pregnancy Loss Susceptibility in the Iranian Population: A Systematic Review and Meta-Analysis Publisher Pubmed



Kamali M1, 2 ; Hantoushzadeh S1 ; Borna S2 ; Neamatzadeh H3, 4 ; Mazaheri M3, 4 ; Noorishadkam M4 ; Haghighi F5
Authors
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Authors Affiliations
  1. 1. Department of Perinatology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Maternal-Fetal and Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  4. 4. Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  5. 5. Department of Gynecology and Obstetrics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Source: Iranian Biomedical Journal Published:2018


Abstract

Studies have indicated that thrombophilic genes polymorphisms are associated with recurrent pregnancy loss (RPL) in the Iranian population. We aimed to evaluate the precise association between thrombophilic genes polymorphisms (MTHFR C677T, MTHFR A1298C, Prothrombin G20210A, FVL G1691A, and PAI-1 4G/5G) and RPL risk in the Iranian population. PubMed, Web of Science, Google Scholar, and ISC were searched for eligible articles published up to April 1, 2017. In total, 37 case-control studies in 18 relevant publications were selected: 1,199, 1,194, 630, 830, and 955 RPL cases and 1,079, 1079, 594, 794, and 499 controls for MTHFR C677T, MTHFR A1298C,Prothrombin G20210A, FVL G1691A, and PAI-1 4G/5G, respectively. The results indicated a significant increased risk of RPL in all genetic models in the population. Also, Prothrombin G20210A and FVL G1691A as well as PAI-1 4G/5G polymorphisms were associated with RPL risk in the Iranian population. Hence, thrombophilic genes polymorphisms are associated with an increased RPL risk in the Iranian population. © 2018, Pasteur Institute of Iran. All rights reserved.
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