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Correlation Between Interleukin-28 Gene Polymorphism With Interleukin-28 Cytokine Levels and Viral Genotypes Among Hcv Patients in Yazd, Iran Publisher Pubmed



Moghimi M1 ; Tavakoli F2 ; Doosti M3, 4 ; Ahmadivasmehjani A2 ; Akhondimeybodi M5
Authors
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Authors Affiliations
  1. 1. Department of Pathology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  2. 2. Virology Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Infectious and Tropical Diseases Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  4. 4. Department of Medical Virology, Faculty of Medical Sciences, Tarbiat Modares University (TMU), Tehran, Iran
  5. 5. Gastroentrology Department, Shahid Sadoughi Hospital, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Source: BMC Research Notes Published:2019


Abstract

Objectives: Recent studies using genome-wide association studies (GWAS) have shown the strong association between polymorphisms near the interleukin-28B (IL-28B) gene and spontaneous clearance of hepatitis C virus (HCV). The present study was designed to evaluate the association of interleukin-28 gene polymorphism with interleukin-28 cytokine levels in different viral genotypes among HCV patients in Yazd, Iran. Result: The most prevalent genotype in chronic cases was genotype 3a, and the lowest one was 2/3a. There were statistically significant differences in genotype frequency between the two studied groups for IL-28B rs12979860C/T. The frequency of CC genotype of IL-28B at rs12979860 SNP was higher in spontaneously cleared patients in comparison with chronic HCV patients. Significant association was found when serum levels of IL28B were compared to various IL-28 genotypes. There was a significant difference between IL-28 polymorphism and HCV genotypes (p = 0.003). © 2019 The Author(s).
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