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Polymorphisms in Egfr and Il28b Are Associated With Spontaneous Clearance in an Hcv-Infected Iranian Population Publisher Pubmed



Carapito R1 ; Poustchi H2 ; Kwemou M1 ; Untrau M1 ; Sharifi AH2 ; Merat S2, 3 ; Hajsheykholeslami A2 ; Jabbari H2 ; Esmaili S2 ; Michel S1 ; Toussaint J1 ; Le Gentil M1 ; Ansarimoghaddam A4 ; Radosavljevic M1 Show All Authors
Authors
  1. Carapito R1
  2. Poustchi H2
  3. Kwemou M1
  4. Untrau M1
  5. Sharifi AH2
  6. Merat S2, 3
  7. Hajsheykholeslami A2
  8. Jabbari H2
  9. Esmaili S2
  10. Michel S1
  11. Toussaint J1
  12. Le Gentil M1
  13. Ansarimoghaddam A4
  14. Radosavljevic M1
  15. Etemadi A2, 5
  16. Georgel P1
  17. Malekzadeh R2, 3
  18. Bahram S1

Source: Genes and Immunity Published:2015


Abstract

Although most hepatitis C virus (HCV)-infected individuals develop chronic infection, about 25% of them are able to clear the virus spontaneously without any therapeutic intervention. The aim of the present study was to identify genes associated with spontaneous HCV clearance in a population of Iranian patients. We genotyped 110 single-nucleotide polymorphisms (SNPs) in 59 selected-candidate-genes in a cohort of 107 HCV-infected participants who spontaneously cleared the infection and 176 participants whose infection persisted. Three out of the 110 SNPs were found to be associated with HCV outcome (P-valueso0.03). rs11506105 in EGFR (epidermal growth factor receptor gene), and rs11881222 and rs12979860 in IL28B (interferon-λ3 gene). Multivariate logistic regression of the three markers showed that the A/A genotypes in both rs11506105 (EFGR) and rs11881222 (IL28B), and the C/C genotype in rs12979860 (IL28B) are associated with HCV clearance (recessive model: odds ratio (OR) = 2.06, 95% confidence interval (95% CI) = 1.09-3.88, P = 0.025; OR = 2.09, 95% CI = 1.23-3.60, P = 0.007; and OR = 1.95, 95% CI = 1.15-3.35, P = 0.014 for rs11506105, rs12979860 and rs11881222, respectively). In conclusion, EGFR and IL28B SNPs are strong independent predictive markers of spontaneous viral clearance. © 2015 Macmillan Publishers Limited All rights reserved.
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