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The Effects of Dietary Supplements in Patients With Cervical Cancer: A Comprehensive Systematic Review Publisher



Gholamalizadeh M1 ; Ardekanizadeh NH2 ; Aghakhaninejad Z3 ; Mohammadi S4 ; Majidi N5 ; Masoumvand M6 ; Bakhshimoghaddam F7 ; Ahmadzadeh M8 ; Tajadod S9 ; Askarpour SA10 ; Khoshdooz S11 ; Kalantari N12 ; Doaei S12
Authors
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Authors Affiliations
  1. 1. Student Research Committee, Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Torbat Jam Faculty of Medical Sciences, Torbat Jam, Iran
  3. 3. Department of Nutrition, Faculty of Public Health, Kerman University of Medical Sciences, Kerman, Iran
  4. 4. Department of Nutrition, Zanjan University of Medical Sciences, Zanjan, Iran
  5. 5. Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran
  6. 6. Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  7. 7. Department of Nutrition, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  8. 8. Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  9. 9. Department of Nutrition, School of Public Health, International Campus, Iran University of Medical Sciences, Tehran, Iran
  10. 10. Division of Food Safety and Hygiene, Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  11. 11. Razi Clinical Research Development Unit, Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran
  12. 12. Department of Community Nutrition, School of Nutrition and Food Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: European Journal of Obstetrics and Gynecology and Reproductive Biology: X Published:2023


Abstract

Background: Recent studies reported that complementary therapy including dietary supplements may has a beneficial role in cervical cancer. However, the results are inconsistent. This study aimed to investigate the association between cervical cancer and dietary supplements. Methods: A systematic literature review was conducted to summarize and quantify the most recent findings on dietary supplement and cervical cancer. Several databases were checked for relevant publications published in English up to March 2023. Of the 32 articles identified, only 20 met the inclusion criteria and were included. Results: Women with cervical intraepithelial neoplasia may benefit from folate supplementation against oxidative stress and inflammation. Vitamin D may reduce oxidative stress and may have a therapeutic effect. Zinc promotes the clearance of the human papilloma virus and reduces the chance of viral infection. The use of probiotic supplements may improve the complications associated with chemotherapy in patients with cervical cancer, such as diarrhea and abdominal pain. Radiotherapy and chemotherapy complications may also be reduced by omega-3 fatty acids. Conclusion: Some dietary supplements including folate, vitamin D, zinc, probiotics, and omega-3 fatty acids may have beneficial effects in patients with cervical cancer. Further studies are warranted to confirm these results. © 2023 The Authors