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Effects of Vitamin D and Omega-3 Fatty Acids Co-Supplementation on Inflammatory Biomarkers, Tumor Marker Cea, and Nutritional Status in Patients With Colorectal Cancer: A Study Protocol for a Double Blind Randomized Controlled Trial Publisher Pubmed



Haidari F1 ; Abiri B2 ; Iravani M3 ; Razavi SM4 ; Sarbakhsh P5 ; Ahmadiangali K6 ; Vafa M7, 8
Authors
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Authors Affiliations
  1. 1. Department of Nutrition, Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  2. 2. Department of Nutrition, Faculty of Paramedicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  3. 3. Department of Oncology and Hematology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Oncology and Hematology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Statistics and Epidemiology, School of Public Health, Tabriz University of Medical Sciences, Tabriz, Iran
  6. 6. Faculty of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  7. 7. Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
  8. 8. Pediatric Growth and Development Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran

Source: Trials Published:2019


Abstract

Background: Much evidence is available demonstrating that both vitamin D and omega-3 fatty acids block the development and progression of colonic carcinogenesis. The results of animal studies have shown that the consumption of omega-3 fatty acids can decrease inflammatory biomarkers, enhance the efficacy of chemotherapy, and decrease the side effects of chemotherapy or cancer. Also, observational studies propose that higher levels of 25(OH)D are related to improved survival of colorectal cancer patients. This study will aim to evaluate the effects of vitamin D and omega-3 fatty acids co-supplementation on inflammatory biomarkers, tumor marker CEA, and nutritional status in colorectal cancer patients. Methods/design: We will carry out an 8-week double-blind randomized, placebo-controlled clinical trial to evaluate the effects of vitamin D and omega-3 fatty acids co-supplementation on inflammatory biomarkers, tumor marker CEA, and nutritional status in patients with stage O€O€ or O€O€O€ colorectal cancer undergoing chemotherapy. Discussion: Because of the important effects of vitamin D and omega-3 fatty acids on molecular pathways involved in cancer development and progression, it seems that both vitamin D and omega-3 fatty acids may provide a new adjuvant therapy by decreasing inflammatory biomarkers and resistance to cancer treatment in patients with colorectal cancer. © 2019 The Author(s).
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