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Differential Expressions of Sirt1, Sirt3, and Sirt4 in Peripheral Blood Mononuclear Cells From Patients With Type 2 Diabetic Retinopathy Publisher Pubmed



Maghbooli Z1 ; Emamgholipour S2 ; Aliakbar S3 ; Amini M4 ; Gorganifiruzjaee S5 ; Hosseinnezhad A6
Authors
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Authors Affiliations
  1. 1. MS Research Center, Neurosciences Institute of Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute of Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Nephrology Department, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Medical Laboratory Sciences, School of Allied Health Medicine, AJA University of Medical Sciences, Tehran, Iran
  6. 6. Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Boston University Medical Center, Boston, MA, United States

Source: Archives of Physiology and Biochemistry Published:2020


Abstract

This study investigated the mRNA and protein levels of SIRT1, SIRT3, and SIRT4 in peripheral blood mononuclear cells (PBMCs) from type 2 diabetes patients with retinopathy (diabetic retinopathy (DR) patients) (n = 86) and those without retinopathy (n = 103). The mRNA expression of SIRT1 and SIRT3 was found to be significantly higher in diabetic patients with retinopathy compared to those without retinopathy. Notably, protein levels of SIRT1, SIRT3, and SIRT4 were higher in patients with DR compared with controls after adjusting for diabetes duration and taking metformin (p =.001 for SIRT1; p =.001 for SIRT3; p =.005 for SIRT4). In the logistic model, there was a significant association between SIRT3 and DR (p =.0001) independent of age and sex and hyperglycaemia markers including FBS, HbA1c, and diabetic duration. These findings suggest an emerging role of sirtuins in the pathogenesis of retinopathy, but further studies are necessary to establish this concept. © 2018 Informa UK Limited, trading as Taylor & Francis Group.
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