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The Effects of Melatonin Supplementation on Mental Health, Metabolic and Genetic Profiles in Patients Under Methadone Maintenance Treatment Publisher Pubmed



Ghaderi A1 ; Banafshe HR1, 2 ; Mirhosseini N3 ; Motmaen M4 ; Mehrzad F4 ; Bahmani F5 ; Aghadavod E5 ; Mansournia MA6 ; Reiter RJ7 ; Karimi MA8 ; Asemi Z5
Authors
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Authors Affiliations
  1. 1. Department of Addiction Studies, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran
  2. 2. Department of Pharmacology, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran
  3. 3. Pure North S'Energy Foundation, Calgary, AB, Canada
  4. 4. Department of Psychiatry, School of Medicine, Kashan University of Medical Science, Kashan, Iran
  5. 5. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran
  6. 6. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Cellular and Structural Biology, University of Texas Health Science, Center, San Antonio, TX, United States
  8. 8. Department of Educational Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran

Source: Addiction Biology Published:2019


Abstract

This investigation was designed to determine the effect of melatonin supplementation on mental health parameters, metabolic and genetic profiles in patients under methadone maintenance treatment (MMT). This randomized, double-blind, placebo-controlled, clinical trial was conducted among 54 patients under MMT. Participants were randomly allocated to receive either 10 mg melatonin (2 melatonin capsules, 5 mg each) (n = 26) or placebo (n = 28) once a day, 1 hour before bedtime for 12 weeks. Melatonin supplementation significantly decreased Pittsburgh Sleep Quality Index (β −4.08; 95 percent CI, −5.51, −2.65; P < 0.001), Beck Depression Inventory index (β −5.46; 95% CI, −8.92, −2.00; P = 0.003) and Beck Anxiety Inventory index (β −3.87; 95% CI, −5.96, −1.77; P = 0.001) and significantly increased International Index of Erectile Functions (β 5.59; 95% CI, 1.76, 9.42; P = 0.005) compared with the placebo. Subjects who received melatonin supplements had significantly lower serum insulin levels (β −2.53; 95% CI, −4.48, −0.59; P = 0.01), homeostasis model of assessment-insulin resistance (β −0.56; 95% CI, −1.03, −0.09; P = 0.01) and higher quantitative insulin sensitivity check index (β 0.01; 95% CI, 0.004, 0.02; P = 0.009) and HDL-cholesterol levels (β 3.71; 95% CI, 1.77, 5.64; P = 0.002) compared to placebo. Additionally, melatonin intake resulted in a significant reduction in serum high sensitivity C-reactive protein (β −0.15; 95% CI, −0.27, −0.02; P = 0.02), malondialdehyde (β −0.31; 95% CI, −0.57, −0.05; P = 0.02) and protein carbonyl (β −0.06; 95% CI, −0.09, −0.04; P < 0.001). This trial indicated that taking melatonin supplements for 12 weeks by patients under MMT had beneficial effects on their mental health metabolic profiles. © 2018 Society for the Study of Addiction
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