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Neuroprotective Effects of Dehydroepiandrosterone and Hericium Erinaceus in Scopolamine-Induced Alzheimer’S Diseases-Like Symptoms in Male Rats Publisher Pubmed



Shirvani M1 ; Nouri F2 ; Sarihi A3, 4 ; Habibi P5 ; Mohammadi M1
Authors
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Authors Affiliations
  1. 1. Department of Pharmacology and Toxicology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran
  2. 2. Department of Pharmaceutical Biotechnology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran
  3. 3. Department of Physiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
  4. 4. Department of Neuroscience, Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
  5. 5. Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Cell Biochemistry and Biophysics Published:2024


Abstract

Background: The neuroprotective effects of Dehydroepiandrosterone (DHEA) and Hericium erinaceus (H. erinaceus) mushroom extract against scopolamine-induced Alzheimer’s disease-like symptoms in male Wistar rats were investigated. Methods: Sixty-four male Wistar rats were divided into eight groups (n = 8). Scopolamine (SCO) was intraperitoneally injected at a dose of 1 mg/kg/day for 10 days. The treatment groups orally received DHEA (250 mg/kg/day) and/or H. erinaceus (300 mg/kg/day) for 14 days. Afterward, the Morris water maze (MWM) and novel object recognition tests were implemented. Then, animals were anesthetized and the brain tissue samples were separated. Levels of lipid peroxidation (LPO), total antioxidant capacity (TAC), catalase activity (CAT), and brain-derived neurotrophic factor (BDNF) were determined. Also, histopathological studies were evaluated in the brain tissue samples. Results: Administration of SCO significantly decreased spatial and cognitive memory (p < 0.001). Not only did SCO injection significantly increase the levels of the LPO but also the SCO markedly reduced the levels of the TAC, CAT activity, and the BDNF in the brain tissue. On the other hand, a combination of the DHEA and H. erinaceus showed higher efficacy than the DHEA or H. erinaceus in attenuating behavioral anomalies and improving the antioxidant defense system and BDNF levels. Histological examination was well correlated with biochemical findings regarding SCO neurodegeneration and DHEA and/or H. erinaceus neuroprotection. Conclusion: Interestingly, ADHE and/or H. erinaceus may due to their potential neurotrophic properties be used as a new and beneficial concurrent therapy in the treatment of Alzheimer’s disease-like symptoms caused by SCO. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.
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