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Minocycline Alleviated Scopolamine-Induced Amnesia by Regulating Antioxidant and Cholinergic Function Publisher



Eshaghi Ghalibaf MH1 ; Rajabian A2 ; Parviz M1, 3 ; Akbarian M4 ; Amirahmadi S5 ; Vafaee F6 ; Hosseini M7
Authors
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Authors Affiliations
  1. 1. Department of Physiology, School of Medicine, Medical Department of Physiology, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  3. 3. Basic Electrophysiology Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  5. 5. Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran
  6. 6. Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  7. 7. Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Source: Heliyon Published:2023


Abstract

Background and aim: Minocycline, a tetracycline derivative, has been found to exert neuroprotective properties. The current project aimed to assess the antioxidant status and cholinergic function in the amnesia induced by scopolamine. Methods: We evaluated the passive avoidance performance, acetylcholine esterase (AChE) enzyme activity, and the oxidative stress indicators in the following groups: Normal control, scopolamine, and the treatment groups (the animals were given minocycline (10–30 mg/kg)). Results: Scopolamine (intraperitoneal) injection was associated with impairment of passive avoidance performance and neurotoxicity. Minocycline pronouncedly ameliorated scopolamine injury as presented by the increased latency time to darkness and stay time in lightness along with the decreased darkness entry. Moreover, minocycline decreased lipid peroxidation, while it elevated the levels of superoxide dismutase, AChE enzymes, and thiol groups in both the cortex and hippocampus. Conclusion: Our data suggested that minocycline modulated the antioxidant status and AChE in the brains, which may contribute to its protective effects against scopolamine-induced amnesia. © 2023
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