Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Ferulago Angulata Methanolic Extract Ameliorates Scopolamine-Induced Memory Impairment Through the Inhibition of Hippocampal Monoamine Oxidase Activity Publisher



Hajimohammadi S1 ; Soodi M1, 2 ; Hajimehdipoor H3 ; Sefidbakht S4 ; Mashhadi Sharif N1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Toxicology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  2. 2. Institute for Natural Products and Medicinal Plants, Tarbiat Modares University, Tehran, Iran
  3. 3. Traditional Medicine and Materia Medica Research Center and Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Department of Pathology, School of Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Metabolic Brain Disease Published:2024


Abstract

Ferulago angulata is a medicinal herb from the Apiaceae family known for its antioxidant, anti-apoptotic, and neuroprotective properties. This study aimed to assess the effects of F. angulata extract on neurobehavioral and biochemical parameters in scopolamine-induced amnesic rats. Fifty-six male Wistar rats were divided into seven groups and orally treated with F. angulata extract (100, 200, 400 mg/kg) and Rivastigmine (1.5 mg/kg) for 10 days. Starting on the sixth day of treatment, the Morris water maze behavioral study was conducted to evaluate cognitive function, with scopolamine administered 30 min before training. Biochemical assays, including monoamine oxidase and oxidative stress measures, were performed on hippocampal tissue. Results showed that extract treatment significantly attenuated scopolamine-induced memory impairment in a dose-dependent manner. Following scopolamine administration, malondialdehyde levels and monoamine oxidase A/B activity increased, while total thiol content and catalase activity decreased compared to the control group. Pretreatment with F. angulata extracts ameliorated the scopolamine-induced impairment in all factors. Toxicological evaluation of liver, lung, heart, and kidney tissues did not indicate any side effects at high doses. The total extract of F. angulata prevents scopolamine-induced learning and memory impairment through antioxidant mechanisms and inhibition of monoamine oxidase. These results suggest that F. angulata extract is effective in the scopolamine model and could be a promising agent for preventing dementia, especially Alzheimer’s disease. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.
Related Docs
View other Related Docs
1. Application of Nanostructured Lipid Carriers: The Prolonged Protective Effects for Sesamol in in Vitro and in Vivo Models of Ischemic Stroke Via Activation of Pi3k Signalling Pathway, DARU# Journal of Pharmaceutical Sciences (2017)
2. Rosmarinic Acid Exerts a Neuroprotective Effect in the Kainate Rat Model of Temporal Lobe Epilepsy: Underlying Mechanisms, Pharmaceutical Biology (2015)
3. Assessment of the Protective Effect of Kn-93 Drug in Systemic Epilepsy Disorders Induced by Pilocarpine in Male Rat, Journal of Cellular Biochemistry (2019)
4. A Camp Analog Attenuates Beta-Amyloid (1–42)-Induced Mitochondrial Dysfunction and Spatial Learning and Memory Deficits, Brain Research Bulletin (2018)
5. Effects of Pm2.5 and Gases Exposure During Prenatal and Early-Life on Autism-Like Phenotypes in Male Rat Offspring, Particle and Fibre Toxicology (2020)
6. Endoplasmic Reticulum Stress Inhibition Ameliorated Wfs1 Expression Alterations and Reduced Pancreatic Islets’ Insulin Secretion Induced by High-Fat Diet in Rats, Scientific Reports (2023)
7. Ellagic Acid Mitigates Sodium Arsenite-Induced Renal and Hepatic Toxicity in Male Wistar Rats, Pharmacological Reports (2018)
8. Pre- and Post-Treatment of Α-Tocopherol on Cognitive, Synaptic Plasticity, and Mitochondrial Disorders of the Hippocampus in Icv-Streptozotocin-Induced Sporadic Alzheimer’S-Like Disease in Male Wistar Rat, Frontiers in Neuroscience (2023)
Experts (# of related papers)
View all Related Experts
Mohammad Sharifzadeh (2)
Rassoul Dinarvand (2)
Other Related Docs
9. Sesamin Imparts Neuroprotection Against Intrastriatal 6-Hydroxydopamine Toxicity by Inhibition of Astroglial Activation, Apoptosis, and Oxidative Stress, Biomedicine and Pharmacotherapy (2017)
10. Neuroprotective Effect of New Nanochelating-Based Nano Complex, Alzc3, Against Aβ (1–42)-Induced Toxicity in Rat: A Comparison With Memantine, Pharmaceutical Research (2020)
11. Protective Role of Apelin-13 on Amyloid Β25–35-Induced Memory Deficit; Involvement of Autophagy and Apoptosis Process, Progress in Neuro-Psychopharmacology and Biological Psychiatry (2019)
12. Effects of Thymol on Amyloid-Β-Induced Impairments in Hippocampal Synaptic Plasticity in Rats Fed a High-Fat Diet, Brain Research Bulletin (2018)
13. Protective Effects of Curcumin and Vitamin E Against Chlorpyrifos-Induced Lung Oxidative Damage, Human and Experimental Toxicology (2015)
14. Rutin, a Quercetin Glycoside, Alleviates Acute Endotoxemic Kidney Injury in C57bl/6 Mice Via Suppression of Inflammation and Up-Regulation of Antioxidants and Sirt1, European Journal of Pharmacology (2018)
15. Effect of Acetyl-L-Carnitine on Antioxidant Status, Lipid Peroxidation, and Oxidative Damage of Arsenic in Rat, Biological Trace Element Research (2016)
16. Satureja Bachtiarica Ameliorate Beta-Amyloid Induced Memory Impairment, Oxidative Stress and Cholinergic Deficit in Animal Model of Alzheimer’S Disease, Metabolic Brain Disease (2016)
17. S-Allyl Cysteine Protects Against Lipopolysaccharide-Induced Acute Kidney Injury in the C57bl/6 Mouse Strain: Involvement of Oxidative Stress and Inflammation, International Immunopharmacology (2019)
18. Ferulic Acid-Loaded Nanostructured Lipid Carriers: A Promising Nanoformulation Against the Ischemic Neural Injuries, Life Sciences (2018)