The Investigation of Conductivity of Magnetic Nanoparticles in the Vascular Network by Dcc Method and the Effect of Forces on the Efficiency of Targeted Magnetic Drug Delivery Publisher



Saadatmand SE¹ ; Kavousi SM¹ ; Alam NR^{1, 2, 3}
Source: Frontiers in Biomedical Technologies Published:2021

Abstract

Purpose: Targeted magnetic drug delivery is one of the methods of cancer treatment. In this method, magnetic factors are conducted inside the body by a variable external magnetic field and deliver the drug agents to the tumor area. The present study aimed to investigate the performance of the drug magnetic conduction by using Differential Current Coil (DCC) and the effect of gravity force on it. Materials and Methods: In mathematical modeling, magnetic, hydrodynamic and gravity forces were assumed to affect the movement of magnetic nanoparticles inside the vessels. Helmholtz coils with a circular cross-section and different currents were simulated in the software environment. The trajectory of nanoparticles within the static fluid, Y-shape channel and multi-branch vascular network was calculated. The relations between the magnetic force applied on the magnetic nanoparticles and the parameters of coil flow, radius and relative permeability of the nanoparticles were investigated. Results: The magnetic flux generated in the coils was calculated and the particles moved in the direction of the magnetic gradient. The diagram of magnetophoresis force changes with the physical parameters was calculated. Particle trajectory and correct exit rate were obtained in simulated vessels. The output changes in the state of with-the-effect and without-the-effect of gravity were about 1.5 to 3%. The output changes of the correct and incorrect branches were calculated by changing the angle of the branches. Conclusion: From the approximate reduction of 2% of the correct output, it can be concluded that the effect of gravity on the conductivity of the system can be neglected. Besides, it seems that as the injection point is closer to the conduction point, the amount of the correct output will increase more. © 2020 Tehran University of Medical Sciences.