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Magnetic Nanoparticles in Cancer Therapy Publisher



Yazdi MK1 ; Zarrintaj P2 ; Khodadadi A3 ; Ganjali MR1, 4 ; Bagheri B5 ; Habibzadeh S6 ; Saeb MR1 ; Mozafari M7
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Authors Affiliations
  1. 1. Center of Excellence in Electrochemistry, School of Chemistry, College of Science, University of Tehran, Tehran, Iran
  2. 2. School of Chemical Engineering, Oklahoma State University, Stillwater, OK, United States
  3. 3. Department of Internal Medicine, School of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran
  4. 4. Biosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South Korea
  6. 6. Department of Chemical Engineering, Amirkabir University of Technology (Tehran Polytechnic), Tehran, Iran
  7. 7. Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada

Source: Magnetic Nanoparticle-Based Hybrid Materials: Fundamentals and Applications Published:2021


Abstract

Magnetic nanoparticles (MNPs) are a very interesting class of metal oxides, which can be magnetized by an external field. The magnetic properties of MNPs give them potential for heat generation and actuation, which are highly appealing for in vivo applications. MNPs can be served as contrast agents for magnetic resonance imaging in cancer screening and diagnosis. Furthermore, they can be loaded with various therapeutics agent or photosensitizers as delivery systems for cancer therapy. Moreover, they can be easily hybridized (functionalized, coated, or combined) with various chemicals which endows them tumor-targeting capability, enhanced biocompatibility, nonimmunogenic properties, enhanced drug-loading capacity, and multimodal imaging capability. This chapter summarizes the current status of MNPs usage in cancer therapy with an emphasis on recent works. Moreover, a brief overview is presented on the importance of mathematical modeling and computer simulation for cancer therapy using MNPs. © 2021 Elsevier Ltd All rights reserved.
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