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Young Adults With Anterior Ischemic Optic Neuropathy: A Multicenter Optic Disc Drusen Study Publisher Pubmed



Hamann S1 ; Malmqvist L1 ; Wegener M1 ; Fard MA2 ; Biousse V2 ; Bursztyn L4 ; Citirak G1 ; Costello F5 ; Crum AV6 ; Digre K6 ; Fraser JA4, 7 ; Hunabaron R8, 9 ; Katz B6 ; Lawlor M10 Show All Authors
Authors
  1. Hamann S1
  2. Malmqvist L1
  3. Wegener M1
  4. Fard MA2
  5. Biousse V2
  6. Bursztyn L4
  7. Citirak G1
  8. Costello F5
  9. Crum AV6
  10. Digre K6
  11. Fraser JA4, 7
  12. Hunabaron R8, 9
  13. Katz B6
  14. Lawlor M10
  15. Newman NJ3
  16. Peragallo JH3
  17. Petzold A11, 12
  18. Sibony PA13
  19. Subramanian PS14
  20. Warner JEA6
  21. Wong SH15
  22. Fraser CL10
Show Affiliations
Authors Affiliations
  1. 1. Department of Ophthalmology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
  2. 2. Farabi Eye Hospital, Tehran University of Medical Science, Tehran, Iran
  3. 3. Departments of Ophthalmology and Neurology, Emory University School of Medicine, Atlanta, GA, United States
  4. 4. Department of Ophthalmology, Western University, London, ON, Canada
  5. 5. Departments of Clinical Neurosciences and Surgery, University of Calgary, Canada
  6. 6. Department of Ophthalmology and Visual Sciences, Department of Neurology, John A. Moran Eye Center, University of Utah, Salt Lake City, UT, United States
  7. 7. Department of Clinical Neurological Sciences, Western University, London, ON, Canada
  8. 8. Goldschleger Eye Institute, Sheba Medical Center, el HaShomer, Israel
  9. 9. Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel
  10. 10. Save Sight Institute Faculty of Health and Medicine, The University of Sydney, Sydney, New South Wales, Australia
  11. 11. Moorfields Eye Hospital, National Hospital for Neurology and Neurosurgery, Queen Square Institute of Neurology, University College of London, London, United Kingdom
  12. 12. Neuro-Ophthalmology Expertise Centre, VU University Medical Center, Amsterdam, Netherlands
  13. 13. Department of Ophthalmology, State University of New York at Stony Brook, Stony Brook, NY, United States
  14. 14. Departments of Ophthalmology, Neurology, and Neurosurgery, Sue Anschutz-Rodgers UC Health Eye Center, University of Colorado School of Medicine, Denver, CO, United States
  15. 15. Department of Neuro-Ophthalmology, Moorfields Eye Hospital, London, United Kingdom

Source: American Journal of Ophthalmology Published:2020


Abstract

Purpose: Optic disc drusen (ODD), present in 2% of the general population, have occasionally been reported in patients with nonarteritic anterior ischemic optic neuropathy (NA-AION). The purpose of this study was to examine the prevalence of ODD in young patients with NA-AION. Design: Retrospective, cross-sectional multicenter study. Methods: All patients with NA-AION 50 years old or younger, seen in neuro-ophthalmology clinics of the international ODDS (Optic Disc Drusen Studies) Consortium between April 1, 2017, and March 31, 2019, were identified. Patients were included if ODD were diagnosed by any method, or if ODD were excluded by enhanced-depth imaging optical coherence tomography (EDI-OCT) using ODDS Consortium guidelines. NA-AION eyes with ODD were termed “ODD-AION”; those without were termed “NODD-AION”. Results: A total of 65 patients (127 eyes) with NA-AION were included (mean 41 years old). Of the 74 eyes with NA-AION, 51% had ODD-AION, whereas 43% of fellow eyes without NA-AION had ODD (P =.36). No significant differences were found between ODD-AION and NODD-AION eyes in terms of Snellen best-corrected VA or perimetric mean deviation. According to EDI-OCT results, 28% of eyes with NODD-AION had peripapillary hyperreflective ovoid mass-like structures (PHOMS); 7% had hyperreflective lines, whereas 54% with ODD-AION had PHOMS; and 66% had hyperreflective lines (P =.006 and P <.001, respectively). Conclusions: Most of these young NA-AION patients had ODD. This indicates that ODD may be an independent risk factor for the development of NA-AION, at least in younger patients. This study suggests ODD-AION be recognized as a novel diagnosis. © 2020 Elsevier Inc.
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