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Micrornas Modulation by Curcumin, Catalpol, and Other Natural Products in Alzheimer’S Disease: A Review Publisher Pubmed



Chahardehi AM1 ; Arefnezhad R1, 2 ; Pourbafrani A3 ; Tajik L4 ; Asadi SA5 ; Salehi H6 ; Yazdanian S7 ; Nakhaee A8 ; Esfahani MS9 ; Behzad P10 ; Haghani H1, 11 ; Niknam Z12 ; Sefati N13 ; Rezaeitazangi F14 Show All Authors
Authors
  1. Chahardehi AM1
  2. Arefnezhad R1, 2
  3. Pourbafrani A3
  4. Tajik L4
  5. Asadi SA5
  6. Salehi H6
  7. Yazdanian S7
  8. Nakhaee A8
  9. Esfahani MS9
  10. Behzad P10
  11. Haghani H1, 11
  12. Niknam Z12
  13. Sefati N13
  14. Rezaeitazangi F14
  15. Tavakoli MR15
Show Affiliations
Authors Affiliations
  1. 1. Coenzyme R Research Institute, Tehran, Iran
  2. 2. Student Research Committee, Fasa University of Medical Sciences, Fasa, Iran
  3. 3. Department of Motor Behavior, Faculty of Physical Education, Allameh Tabatbai University, Tehran, Iran
  4. 4. Faculty of Medicine, Islamic Azad University Tehran Medical Sciences, Tehran, Iran
  5. 5. Birjand University of Medical Sciences, Birjand, Iran
  6. 6. Department of Physiology, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Hamedan University of Medical Sciences, Hamedan, Iran
  8. 8. Mashhad University of Medical Sciences, Mashhad, Iran
  9. 9. Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  10. 10. Science and Research Branch, Islamic Azad University, Tehran, Iran
  11. 11. Department of Biotechnology, Islamic Azad University, Yadegar-e-Imam Khomeini (RAH) City of Rey Branch, Tehran, Iran
  12. 12. Neurophysiology Research Center, Cellular and Molecular Medicine Research Institute, Urmia University of Medical Sciences, Urmia, Iran
  13. 13. Department of Anatomy, School of Medicine, Arak University of Medical Sciences, Arak, Iran
  14. 14. Department of Anatomy, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran
  15. 15. Pharmaceutical Sciences and Cosmetic Products Research Center, Kerman University of Medical Sciences, Kerman, Iran

Source: Molecular Biology Reports Published:2025


Abstract

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with limited pharmacological treatment options, necessitating the exploration of alternative therapeutic strategies. Emerging evidence suggests that microRNAs (miRNAs), such as miR-132, miR-34a, and miR-124, play crucial roles in AD pathogenesis, influencing amyloid-beta (Aβ) aggregation, tau phosphorylation, neuroinflammation, and oxidative stress. Natural products have been identified as potential modulators of miRNA expression, offering neuroprotective benefits through multi-target mechanisms. This review systematically examines the impact of curcumin, catalpol, Allium jesdianum, Tanshinone IIA (Tan IIA), and Tiaoxin Recipe (TXR) on miRNA regulation in AD, summarizing their molecular targets and therapeutic potential. Furthermore, we discuss challenges related to bioavailability and clinical translation, highlighting the need for advanced delivery systems and personalized medicine approaches. By integrating recent findings, this review provides a comprehensive perspective on the role of miRNA modulation in AD therapy and underscores the potential of natural products as novel therapeutic agents. © The Author(s), under exclusive licence to Springer Nature B.V. 2025.
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