No Evidence of Occult Hbv Infection in Population Born After Mass Vaccination

No Evidence of Occult Hbv Infection in Population Born After Mass Vaccination Publisher Pubmed

Aghasadeghi MR¹ ; Aghakhani A² ; Mamishi S³ ; Bidarizerehpoosh F⁴ ; Haghi Ashtiani MT⁵ ; Sabeti S⁴ ; Banifazl M⁶ ; Karami A⁷ ; Bavand A² ; Ramezani A²

Show Affiliations

1. Hepatitis and AIDS Dept., Pasteur Institute of Iran, Tehran, Iran
2. Clinical Research Dept., Pasteur Institute of Iran, Pasteur Ave., Tehran, 13164, Iran
3. Pediatric Infectious Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran
4. Pathology Ward, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5. Pediatrics Center of Excellence, Childrenâ€™s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
6. Iranian Society for Support of Patients with Infectious Disease, Tehran, Iran
7. Zanjan University of Medical Sciences, Zanjan, Iran

Source: Wiener Medizinische Wochenschrift Published:2020

Abstract

Despite access to efficient hepatitis B virus (HBV) vaccine and universal immunization schedules, HBV infection remains a global health concern. HBV infection has decreased by this program. Nevertheless, breakthrough infections occur due to generation of occult HBV infection (OBI) and surface gene mutants in the immunized population. We aimed to determine the presence of OBI in a population born after initiation of nationwide HBV vaccination in Tehran, Iran. A HBV mass vaccination schedule was launched in Iran in 1993. For this study, we enrolled 1120 cases younger than 24 years. ELISA was applied to evaluate the presence of HBsAg, anti-HBs and anti-HBc. HBV-DNA presence was determined in all HBsAg-negative cases using nested polymerase chain reaction. The prevalence of HBsAg, anti-HBc and anti-HBs was 0.1, 0.54 and 39.9% respectively. Out of 6 anti-HBc-positive individuals, 4 cases also had anti-HBs. One case revealed HBsAg co-existence and the other one showed isolated anti-HBc. HBV-DNA was not detected in HBsAg-negative specimens. A very low prevalence of HBsAg and isolated anti-HBc was observed and no occult HBV infection was detected. It seems that evasion mutants are not a potential threat for HBV universal immunization efficacy in the vaccinated population. © 2020, Springer-Verlag GmbH Austria, ein Teil von Springer Nature.

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Style	Citing Format
MLA	Aghasadeghi MR, et al.. "No Evidence of Occult Hbv Infection in Population Born After Mass Vaccination." Wiener Medizinische Wochenschrift, vol. 170, no. 9-10, 2020, pp. 218-223.
APA	Aghasadeghi MR, Aghakhani A, Mamishi S, Bidarizerehpoosh F, Haghi Ashtiani MT, Sabeti S, Banifazl M, Karami A, Bavand A, Ramezani A (2020). No Evidence of Occult Hbv Infection in Population Born After Mass Vaccination. Wiener Medizinische Wochenschrift, 170(9-10), 218-223.
Chicago	Aghasadeghi MR, Aghakhani A, Mamishi S, Bidarizerehpoosh F, Haghi Ashtiani MT, Sabeti S, Banifazl M, Karami A, Bavand A, Ramezani A. "No Evidence of Occult Hbv Infection in Population Born After Mass Vaccination." Wiener Medizinische Wochenschrift 170, no. 9-10 (2020): 218-223.
Harvard	Aghasadeghi MR et al. (2020) 'No Evidence of Occult Hbv Infection in Population Born After Mass Vaccination', Wiener Medizinische Wochenschrift, 170(9-10), pp. 218-223.
Vancouver	Aghasadeghi MR, Aghakhani A, Mamishi S, Bidarizerehpoosh F, Haghi Ashtiani MT, Sabeti S, et al.. No Evidence of Occult Hbv Infection in Population Born After Mass Vaccination. Wiener Medizinische Wochenschrift. 2020;170(9-10):218-223.
BibTex	@article{ author = {Aghasadeghi MR and Aghakhani A and Mamishi S and Bidarizerehpoosh F and Haghi Ashtiani MT and Sabeti S and Banifazl M and Karami A and Bavand A and Ramezani A}, title = {No Evidence of Occult Hbv Infection in Population Born After Mass Vaccination}, journal = {Wiener Medizinische Wochenschrift}, volume = {170}, number = {9-10}, pages = {218-223}, year = {2020} }
RIS	TY - JOUR AU - Aghasadeghi MR AU - Aghakhani A AU - Mamishi S AU - Bidarizerehpoosh F AU - Haghi Ashtiani MT AU - Sabeti S AU - Banifazl M AU - Karami A AU - Bavand A AU - Ramezani A TI - No Evidence of Occult Hbv Infection in Population Born After Mass Vaccination JO - Wiener Medizinische Wochenschrift VL - 170 IS - 9-10 SP - 218 EP - 223 PY - 2020 ER -

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