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Clinical and Translational Advances in Regulatory T Cell-Based Strategies in Allogeneic Hematopoietic Stem Cell Transplantation: Highlights From Ash 2025 Publisher



Yazdanparast S ; Abroun S ; Rostami T ; Mohammadi S
Authors

Source: Experimental Hematology and Oncology Published:2026


Abstract

Regulatory T cells (Tregs), winners of the 2025 Nobel Prize in Physiology or Medicine, emerged as an unsung giant of peripheral immune tolerance after allogeneic hematopoietic stem cell transplantation (allo-HSCT). These cells exert influence across four interconnected immunological axes encompassing graft-versus-leukemia (GVL), graft-versus-host disease (GVHD), relapse, and viral infection. This correspondence highlights key advancements in Treg-based interventions in allo-HSCT, ranging from basic research to clinical applications, as presented at the ASH 2025 Annual Meeting. Accordingly, Tregs are used as GVHD prophylaxis via the Orca-T platform and as a therapeutic strategy for steroid-refractory (SR)-GVHD patients. Experimental studies further pave the way to address existing limitations toward next-generation Treg-based cell therapy in allo-HSCT. © The Author(s) 2026.
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