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The Role of T Regulatory Cells in Immunopathogenesis of Myasthenia Gravis: Implications for Therapeutics Publisher Pubmed



Alahgholihajibehzad M1 ; Kasapoglu P1 ; Jafari R2 ; Rezaei N3, 4, 5
Authors
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Authors Affiliations
  1. 1. Department of Immunology, Institute of Experimental Medicine (DETAE), Istanbul University, Istanbul, Turkey
  2. 2. Research Center for Immunology, Tabriz University of Medical Science, Tabriz, Iran
  3. 3. Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Science, Tehran, Iran
  4. 4. Department of Immunology, School of Medicine, Tehran University of Medical Science, Tehran, Iran
  5. 5. Universal Scientific Education and Research Network (USERN), Tehran, Iran

Source: Expert Review of Clinical Immunology Published:2015


Abstract

T regulatory cells (Tregs) are crucial for the development of self-tolerance and are the major focus in many studies interpreting the pathogenesis of myasthenia gravis (MG), an autoimmune-based disease. In normal conditions, Tregs regulate the immune responses, while impaired regulatory function of these cells can lead to autoimmunity. Recent studies have confirmed that the thymic and peripheral blood CD4+CD25+ Tregs of MG are defective in functions and/or in numbers, which are associated with disease severity; approaches to correct the defects of these Tregs may be promising in the treatment of MG. This review discusses recent studies on characteristics, quantitative and qualitative changes of Tregs and possible mechanisms that are involved in the impairment of these cells in MG pathogenesis. In addition, new approaches inducing Treg generation that are currently being investigated as therapies for MG, will be discussed as well as proposed approaches for future therapies. © Informa UK, Ltd.
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