Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Association of Neutrophil to Lymphocyte Ratio With Bone Mineral Density in Post-Menopausal Women: A Systematic Review and Meta-Analysis Publisher Pubmed



Salimi M1 ; Khanzadeh M2 ; Nabipoorashrafi SA4 ; Seyedi SA4 ; Yaghoobpoor S5 ; Brismee JM6 ; Luckewold B7 ; Ebadi M8 ; Ghaedi A9 ; Kumar VS10 ; Mirghaderi P11 ; Rabie H12 ; Khanzadeh S13
Authors
Show Affiliations
Authors Affiliations
  1. 1. Bone and Joint Diseases Research Center, Department of Orthopedic Surgery, Shiraz University of Medical Sciences, Shiraz, Iran
  2. 2. Geriatric & amp
  3. 3. Gerontology Department, Medical School, Tehran University of medical and health sciences, Tehran, Iran
  4. 4. Endocrinology and Metabolism Research Center (EMRC), School of Medicine, Vali-Asr Hospital, Tehran, Iran
  5. 5. Student Research Committee, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Center for Rehabilitation Research, Department of Rehabilitation Sciences, Texas Tech University Health Sciences Center, Lubbock, TX, United States
  7. 7. Department of Neurosurgery, University of Florida, Gainesville, United States
  8. 8. Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran
  9. 9. Student Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  10. 10. Department of Orthopaedic Surgery, Ohio State University Wexner Medical Center, Columbus, OH, United States
  11. 11. Students’ Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran
  12. 12. Department of Orthopedic Surgery, Tehran University of Medical Sciences, Tehran, Iran
  13. 13. Tabriz University of Medical Sciences, Tabriz, Iran

Source: BMC Women's Health Published:2024


Abstract

Background: We conducted a systematic review and meta-analysis to compare the neutrophil lymphocyte ratio (NLR) levels between women with post-menopausal osteopenia or osteoporosis to those with normal bone mineral density (BMD). Methods: We used Web of Science, PubMed, and Scopus to conduct a systematic search for relevant publications published before June 19, 2022, only in English language. We reported standardized mean difference (SMD) with a 95% confidence interval (CI). Because a significant level of heterogeneity was found, we used the random-effects model to calculate pooled effects. We used the Newcastle–Ottawa scale for quality assessment. Results: Overall, eight articles were included in the analysis. Post-menopausal women with osteoporosis had elevated levels of NLR compared to those without osteoporosis (SMD = 1.03, 95% CI = 0.18 to 1.88, p = 0.017, I2 = 98%). In addition, there was no difference between post-menopausal women with osteopenia and those without osteopenia in neutrophil lymphocyte ratio (NLR) levels (SMD = 0.58, 95% CI=-0.08 to 1.25, p = 0.085, I2 = 96.8%). However, there was no difference between post-menopausal women with osteoporosis and those with osteopenia in NLR levels (SMD = 0.75, 95% CI=-0.01 to 1.51, p = 0.05, I2 = 97.5%, random-effect model). Conclusion: The results of this study point to NLR as a potential biomarker that may be easily introduced into clinical settings to help predict and prevent post-menopausal osteoporosis. © The Author(s) 2024.
Related Docs
1. Meta-Analysis of the Relationship Between Neutrophil to Lymphocyte Ratio and Nasal Polyps, Indian Journal of Otolaryngology and Head and Neck Surgery (2024)
2. Diabetes Mellitus and Osteoporosis Correlation: Challenges and Hopes, Current Diabetes Reviews (2020)
Experts (# of related papers)
Raziyeh Mohammad Jafari (1)
Ahmad Reza Dehpour (1)